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EGF — RASA1

Text-mined interactions from Literome

Lockyer et al., Curr Biol 1999 : This recruitment required a functional GAP1 ( m ) pleckstrin homology (PH) domain, because a specific point mutation ( R629C ) in the PH domain that inhibits IP4 binding in vitro [ 5 ] totally blocked EGF induced GAP1 ( m ) translocation
Lock et al., J Biol Chem 1999 : Stimulation of BaF/3 hematopoietic cells co-expressing the epidermal growth factor (EGF) receptor tyrosine kinase and FLAG-DokR with EGF also induced phosphorylation of FLAG-DokR and promoted its association with GAP
Van Slyke et al., Mol Cell Biol 2005 (Breast Neoplasms) : Dok-R 's ability to attenuate EGF-driven MAPK activation is independent of its ability to recruit rasGAP , a known attenuator of MAPK activity, suggesting an alternate Dok-R mediated pathway
Kawase et al., Dev Cell 2006 : We propose that an EGF stimulated GAP accelerates GTP hydrolysis of TC10, thereby promoting vesicle fusion
Yasuda et al., FEBS Lett 2007 : Interestingly, DGKgamma markedly augmented EGF dependent GAP activity of beta2-chimaerin through its catalytic action
Auricchio et al., FEBS Lett 1994 : In addition EGF induces stable association of the GTP-ase activating protein of p21ras to the p190 protein and to a 62 mol.wt
Soler et al., Oncogene 1994 : In contrast to EGF induced tyrosine phosphorylation of the GTPase activating protein for ras ( rasGAP ) and phospholipase C-gamma 1 ( PLC-gamma 1 ), SHC tyrosine phosphorylation occurs at a very low receptor density in parental NIH3T3 mouse fibroblasts expressing less than 1 x 10 ( 4 ) EGF receptors per cell
Soler et al., Cell Growth Differ 1994 : EGF stimulates RasGAP protein synthesis and does not affect its degradation rate ... The mechanism for RasGAP protein induction by EGF involves an increase in rasGAP mRNA levels
Buday et al., Mol Cell Biol 1993 : EGF had no effect on total GTPase activating protein activity
Dougall et al., DNA Cell Biol 1996 : In addition, the EGF induced phosphorylation of GAP , p85, and PLC-gamma 1 did not correlate with the dominant negative action of p185K757M on EGFr function
Wang et al., Cell Growth Differ 1996 : Association of p120 ras GAP with endocytic components and colocalization with epidermal growth factor (EGF) receptor in response to EGF stimulation ... Herein we show by subcellular fractionation, immunoprecipitation and Western blotting, indirect immunofluorescence, and double immunogold labeling and electron microscopy that, in response to EGF stimulation of MDCK cells, GAP becomes first plasma membrane localized and subsequently internalized with EGF receptors