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IRS1 — SH2B1

Pathways - manually collected, often from reviews:

• Reactome Reaction: IRS1 → SH2B1 (direct_complex) Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997
• Reactome Reaction: IRS1 → SH2B1 (reaction) Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRS1 — SH2B1 (direct interaction, unspecified method) Liu et al., Cell communication and signaling : CCS 2012

Text-mined interactions from Literome

Duan et al., Mol Cell Biol 2004 (Glucose Intolerance...) : Moreover, SH2-B directly enhanced autophosphorylation of insulin receptor and tyrosine phosphorylation of IRS1 and IRS2 in an SH2 domain dependent manner in cultured cells
Duan et al., J Biol Chem 2004 : Consequently, SH2-B dramatically enhanced leptin stimulated tyrosine phosphorylation of IRS1 and IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt ... Similarly, SH2-B promoted growth hormone stimulated tyrosine phosphorylation of IRS1 in both HEK293 and MEF cells