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LCK — PLAU

Text-mined interactions from Literome

Mahabeleshwar et al., J Biol Chem 2003 (Anoxia...) : To our knowledge, this is the first report that p56lck in presence of H/R regulates NFkappaB activation, uPA secretion, and cell motility through tyrosine phosphorylation of IkappaBalpha and further demonstrates an important redox regulated pathway for NFkappaB activation following H/R injury that is independent of IkappaB kinase/IkappaBalpha mediated signaling pathways
Mahabeleshwar et al., J Biol Chem 2004 (Anoxia...) : DN Lck and inhibitors of Lck, EGF receptor, and MEK-1 suppressed H/R induced uPA secretion and cell motility
Chakraborty et al., J Biol Chem 2006 (Anoxia...) : Moreover, Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM), urokinase-type plasminogen activator ( uPA ), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk inhibited the H/R induced uPA , MMP-9, and VEGF expression but up-regulated MelCAM expression