UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to INSR

INSR — YWHAE

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: INSR → Complex of INSR-YWHAE (decreases, INSR/YWHAE Activity)
Evidence: both the insulin receptor and IRS proteins undergo serine phosphorylation, which may attenuate signalling by decreasing insulin-stimulated tyrosine phosphorylation19 and promote interaction with 14-3-3 proteins20.
OpenBEL Selventa BEL large corpus: INSR → Complex of IRS1-YWHAE (decreases, IRS1/YWHAE Activity)
Evidence: both the insulin receptor and IRS proteins undergo serine phosphorylation, which may attenuate signalling by decreasing insulin-stimulated tyrosine phosphorylation19 and promote interaction with 14-3-3 proteins20.
OpenBEL Selventa BEL large corpus: INSR → Complex of IRS2-YWHAE (decreases, IRS2/YWHAE Activity)
Evidence: both the insulin receptor and IRS proteins undergo serine phosphorylation, which may attenuate signalling by decreasing insulin-stimulated tyrosine phosphorylation19 and promote interaction with 14-3-3 proteins20.