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IL18 — PTGS2
Text-mined interactions from Literome
Fosslien et al., Ann Clin Lab Sci 2000
(Carcinoma, Squamous Cell...) :
COX-2 is
inducible by oncogenes ras and scr,
interleukin-1 , hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha
Nédélec et al., Biochem Pharmacol 2001
:
In monolayers,
interleukin-1beta (IL-1beta)
induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Moore et al., J Appl Physiol 2001
:
In human cultured airway smooth muscle cells,
interleukin (IL)-1 beta
increases cyclooxygenase
(COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Soloff et al., Endocrinology 2004
:
In situ analysis of
interleukin-1 induced transcription of
cox-2 and il-8 in cultured human myometrial cells
Oku et al., Hum Reprod 2004
(Endometriosis) :
The
effects of
IL-18 on cyclooxygenase
(COX)-II gene expression were analysed in peritoneal fluid monocytes and endometriotic cells of endometriosis patients ...
COX-II was induced in peritoneal fluid monocytes and in endometriotic cells in
response to
IL-18 stimulation ... The elevation of IL-18 in the peritoneal fluid of endometriosis patients and the
induction of
COX-II in peritoneal monocytes by
IL-18 suggest that IL-18 plays a pathogenic role in endometriosis
Lee et al., Proc Natl Acad Sci U S A 2004
(Fever...) :
After 30 h,
IL-18 induced
COX-2 appeared in part to be IL-1 dependent
Stamp et al., J Rheumatol 2004
:
Paracrine upregulation of monocyte
cyclooxygenase-2 by mediators produced by T lymphocytes :
role of
interleukin 17 and interferon-gamma
Attar et al., Hum Reprod Update 2006
(Endometriosis...) :
COX-2 in turn is
stimulated by E ( 2 ),
interleukin-1beta (IL-1beta) and PGE ( 2 ) itself in endometrial and endometriotic cells
Wu et al., Prostaglandins Other Lipid Mediat 2007
:
In this review, we provide evidence for reduced
COX-2 transcriptional expression in
response to phorbol esters ( PMA ), lipopolysaccharide (LPS),
interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)
Wu et al., Reprod Sci 2007
(Endometriosis) :
These results, along with recent findings that TSA suppresses proliferation,
interleukin-1 beta
induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
Vinukonda et al., Brain 2010
(Disease Models, Animal...) :
Cyclooxygenase-2 or prostanoid receptor-1 inhibition
reduced tumour necrosis factor-a level, but not
interleukin-1ß
Martín et al., J Hypertens 2012
:
This study analyzes the effect of pioglitazone, a PPAR? agonist, on
interleukin-1ß induced
COX-2 expression and the role of reactive oxygen species ( ROS ) on this effect ... PPAR? activation with pioglitazone reduces
interleukin-1ß induced
COX-2 expression by interference with the redox-sensitive transcription factor NF-?B
Seo et al., Immunopharmacol Immunotoxicol 2012
(Inflammation) :
SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ),
interleukin-6 , and tumor necrosis factor-a and
inhibited the expression of iNOS and
COX-2 via attenuation of NF-?B p65 expression
Wu et al., Basic Clin Pharmacol Toxicol 2012
(Inflammation) :
It was found that licofelone attenuated
interleukin-18 induced
COX-2 enzyme activity in HMC and prostaglandin E2 release in a dose dependent manner
Szczepanski et al., Arthritis Rheum 1994
:
Induction of
cyclooxygenase II in human synovial microvessel endothelial cells by
interleukin-1
Feng et al., Arch Biochem Biophys 1993
:
In rat vascular smooth muscle cells,
interleukin-1 beta selectively
increased the expression of
COX-2 , but not that of COX-1, as assessed by enzyme activity, immunoprecipitation of COX proteins, and mRNA analysis
Crofford et al., Arthritis Rheum 1997
(Arthritis, Rheumatoid) :
Involvement of nuclear factor kappa B in the
regulation of
cyclooxygenase-2 expression by
interleukin-1 in rheumatoid synoviocytes
Kniss et al., Am J Obstet Gynecol 1997
:
Interleukin-1 receptor antagonist blocks
interleukin-1 induced expression of
cyclooxygenase-2 in endometrium ... Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress
interleukin-1 induced
cyclooxygenase-2 expression
Staels et al., Nature 1998
(Coronary Disease...) :
In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit
interleukin-1 induced production of interleukin-6 and prostaglandin and expression of
cyclooxygenase-2
Longo et al., Mediators Inflamm 1998
:
The
role of cyclooxygenase-1 and
cyclooxygenase-2 in lipopolysaccharide and
interleukin-1 stimulated enterocyte prostanoid formation