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CD80 — IL2

Text-mined interactions from Literome

Rückert et al., J Invest Dermatol 2002 (Dermatitis, Contact) : IL-2-IgG2b but not IL-15-IgG2b fusion protein reduced migration of antigen presenting cells from the skin to local lymph nodes, inhibited the expression of CD80 and CD86, and induced a significant higher number of CD4+CD25+ T cells
Blanchet et al., Am J Respir Crit Care Med 2004 (Alveolitis, Extrinsic Allergic) : To test the effect of nicotine on alveolar macrophages, AMJ2-C11 cells were treated with nicotine and stimulated with lipopolysaccharide or Saccharopolyspora rectivirgula, a causative agent of HP. Nicotine reduced tumor necrosis factor release and tumor necrosis factor, interleukin-10 , and IFN-gamma mRNA expression after stimulation and decreased CD80 expression by 55 % in lipopolysaccharide stimulated cells and by 41 % in S. rectivirgula stimulated cells
Spaner et al., Br J Haematol 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : IL-2 improved the ability of CLL cells to stimulate T cell proliferation and increased the expression of costimulatory molecules ( particularly CD80 ) in a dose dependent fashion, especially in CLL cells with weak expression of CD38 ... CD80 and CD86 induction by IL-2 were positively regulated through the mitogen activated protein kinase pathway, while CD86 expression was negatively regulated through Janus kinase pathways
Xia et al., J Immunol 2006 (Neoplasms) : CD8+ cytotoxic T-APC stimulate central memory CD8+ T cell responses via acquired peptide-MHC class I complexes and CD80 costimulation , and IL-2 secretion ... Interestingly, the stimulatory effect of Tc-APC is mediated via its IL-2 secretion and acquired CD80 costimulation , and is specifically targeted to OVA-specific CD8+ T cells in vivo via its acquired pMHC I complexes
Hao et al., J Immunol 2007 (Neoplasms) : We further elucidate that the EXO ( OVA ) -uptaken ( targeted ) CD4+ aT cell 's stimulatory effect is mediated via its IL-2 secretion and acquired exosomal CD80 costimulation and is specifically delivered to CD8+ T cells in vivo via acquired exosomal peptide/MHC class I complexes
Lanier et al., J Immunol 1995 (Mast-Cell Sarcoma) : When we used small, resting human peripheral blood T cells as responders, both CD80 and CD86 transfectants efficiently costimulated anti-CD3 mAb induced proliferation and the secretion of IL-2 and IFN-gamma
Lando et al., J Immunol 1996 : Large amounts of IL-2 , IFN-gamma, and TNF were produced in addition to an increase in IL-2 mRNA as a result of CD80 costimulation
Zissel et al., J Investig Med 1997 (Lung Diseases, Interstitial...) : Alveolar macrophages from patients with arcoidosis, TB, and HB express the costimulatory molecule CD80 on their surface and anti-CD80 antibodies inhibited the IL-2 release of Jurkat cells in this system to 59 +/- 27 %
Olsson et al., Int Immunol 1998 : CD80 induced higher levels of IL-2 promoter-enhancer activity compared to CD86