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PRKCA — RAC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Slater et al., Biochemistry 2001
:
It was found that the activity of
PKCalpha was potently
enhanced by RhoA and Cdc42 and to a lesser extent by
Rac1 , whereas the effects on the activities of PKCbetaI, -betaII, -gamma, -delta, -epsilon, and -zeta were much reduced
Bass et al., J Cell Biol 2007
:
In wild-type fibroblasts, syndecan-4 mediates the matrix induced
protein kinase Calpha (PKCalpha) dependent activation of
Rac1 and localizes Rac1 activity and membrane protrusion to the leading edge of the cell, resulting in persistent migration
Kim et al., Mol Immunol 2008
(Dermatitis, Allergic Contact...) :
PKCalpha and -delta were
responsible for increased
Rac1 activity and expression of p47(phox), p67(phox)
Kim et al., J Biol Chem 2008
:
Protein kinase C (PKC)-alpha and PKCdelta were
responsible for increased
Rac1 activity, production of ROS, and mediated HA-promoted cell motility
Putnam et al., Cell communication and signaling : CCS 2009
:
Loss of
PKCalpha expression, but not PKCdelta, by siRNA
inhibited Rac and PAK activity as well as invasiveness