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EPHB2 — LYN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
→
FAP1 (PTPN13)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Palmer et al., Mol Cell 2002
Evidence: assay
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Palmer et al., Mol Cell 2002
Evidence: assay
-
Reactome Reaction:
LYN
→
EPHB2
(indirect_complex)
-
Reactome Reaction:
LYN
→
EPHB2
(direct_complex)
-
Reactome Reaction:
LYN
→
EPHB2
(reaction)
Marignani et al., J Cell Biol 2001, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005, Tolias et al., Proc Natl Acad Sci U S A 2007
Text-mined interactions from Literome
Arai et al., J Biol Chem 2001
:
Overexpression of
Lyn induced constitutive phosphorylation of CrkL and activation of
Erk , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk
Su et al., Molecular cancer 2012
(Colorectal Neoplasms...) :
Lyn is
involved in CD24 induced
ERK1/2 activation in colorectal cancer ... The results of the Co-IP and immunofluorescence assay revealed that overexpression of CD24 enhanced the interaction of Lyn and
ERK1/2 and
induced the nuclear translocation of
Lyn ... However, inhibition of
Lyn activity
attenuated CD24 induced
ERK1/2 activation, and depletion of CD24 disrupted Lyn-ERK1/2 interaction ... Our results suggest that
Lyn is
involved in CD24 induced
ERK1/2 activation in CRC