◀ Back to FYN
FYN — GRIN2A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Reelin signaling pathway:
GRIN2A (GRIN2A)
→
GRIN2B/RELN/LRP8/DAB1/Fyn complex (GRIN2B-LRP8-RELN-FYN-DAB1)
(modification, collaborate)
Sinagra et al., J Neurosci 2005, Chen et al., J Neurosci 2005
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
GRIN2A (GRIN2A)
→
GRIN2A/RELN/LRP8/DAB1/Fyn complex (GRIN2A-LRP8-RELN-FYN-DAB1)
(modification, collaborate)
Sinagra et al., J Neurosci 2005, Chen et al., J Neurosci 2005
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
GRIN2A (GRIN2A)
→
RELN/LRP8/DAB1/Fyn complex (RELN-LRP8-FYN-DAB1)
(modification, collaborate)
Sinagra et al., J Neurosci 2005, Chen et al., J Neurosci 2005
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
GRIN2B (GRIN2B)
→
GRIN2A/RELN/LRP8/DAB1/Fyn complex (GRIN2A-LRP8-RELN-FYN-DAB1)
(modification, collaborate)
Sinagra et al., J Neurosci 2005, Chen et al., J Neurosci 2005
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
GRIN2B/RELN/LRP8/DAB1/Fyn complex (GRIN2B-LRP8-RELN-FYN-DAB1)
→
GRIN2A/RELN/LRP8/DAB1/Fyn complex (GRIN2A-LRP8-RELN-FYN-DAB1)
(modification, collaborate)
Sinagra et al., J Neurosci 2005, Chen et al., J Neurosci 2005
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
GRIN2A/RELN/LRP8/DAB1/Fyn complex (GRIN2A-LRP8-RELN-FYN-DAB1)
→
RELN/LRP8/DAB1/Fyn complex (RELN-LRP8-FYN-DAB1)
(modification, collaborate)
Sinagra et al., J Neurosci 2005, Chen et al., J Neurosci 2005
Evidence: assay, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
FYN
—
GRIN2A
(physical association, affinity chromatography technology)
Tezuka et al., Proc Natl Acad Sci U S A 1999*
-
IRef Biogrid Interaction:
FYN
—
GRIN2A
(physical association, affinity chromatography technology)
Ma et al., Neurosci Lett 2003*
-
IRef Biogrid Interaction:
FYN
—
GRIN2A
(physical association, affinity chromatography technology)
Hou et al., Brain Res 2002*
-
IRef Biogrid Interaction:
FYN
—
GRIN2A
(direct interaction, pull down)
Takagi et al., J Cereb Blood Flow Metab 1999*
-
IRef Biogrid Interaction:
FYN
—
GRIN2A
(physical association, affinity chromatography technology)
Takagi et al., J Cereb Blood Flow Metab 1999*
-
MIPS CORUM PSD95-FYN-NR2A complex:
PSD95-FYN-NR2A complex complex (DLG4-FYN-GRIN2A)
Tezuka et al., Proc Natl Acad Sci U S A 1999*
-
IRef Corum Interaction:
Complex of FYN-DLG4-GRIN2A
(association, anti bait coimmunoprecipitation)
Tezuka et al., Proc Natl Acad Sci U S A 1999*
-
IRef Ophid Interaction:
FYN
—
GRIN2A
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Isosaka et al., Brain Res 2006
:
We also found that the increase in
NR2A and NR2B proteins in heterozygous reeler was
dependent on
Fyn , because this change was absent in heterozygous reeler/homozygous Fyn-deficient double-mutant mice
Woodward et al., Alcohol Clin Exp Res 2006
(Alcoholism...) :
In the first presentation, Dorit Ron presented data showing how activation of
Fyn or Src tyrosine kinases differentially
regulated the cell surface expression and activity of
NR2A and NR2B containing NMDA receptors
Knox et al., Neurobiol Dis 2013
(Hypoxia-Ischemia, Brain) :
Neuronal
Fyn overexpression
led to sustained
NR2A and NR2B tyrosine phosphorylation and enhanced NR2B phosphorylation at tyrosine ( Y ) 1472 and Y1252 in synaptic membranes
Tezuka et al., Proc Natl Acad Sci U S A 1999
:
Results also showed that PSD-95, which directly binds to and coclusters with NMDA receptors, promotes
Fyn mediated tyrosine phosphorylation of
NR2A