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CEBPB — TFAP2A
Text-mined interactions from Literome
Maytin et al., Dev Biol 1999
:
This novel regulatory scheme involves : ( 1 ) unique gradients of expression for each transcription factor, i.e., C/EBPbeta and AP-2 most abundant in the lower epidermis, C/EBPalpha in the upper ; ( 2 ) C/EBP binding sites in the ap-2alpha gene promoter, through which
C/EBPbeta stimulates
ap-2alpha ; and ( 3 ) AP-2 binding sites in the c/ebpalpha promoter, through which AP-2 represses c/ebpalpha
Costa et al., Endocr Relat Cancer 2008
(Breast Neoplasms...) :
Using glutathione S-transferase pull-down assays combined with electrophoretic mobility shift assay and chromatin immunoprecipitation, we demonstrated that by interacting with Sp1, C/EBPbeta, and
AP-2 , PPARgamma can prevent Sp1/AP-2 protein-protein association and
inhibit binding of Sp1 and
C/EBPbeta to DNA, thus reducing IR gene transcription