Gene interactions and pathways from curated databases and text-mining

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EPHB2 — MAP3K12

Text-mined interactions from Literome

Roux et al., J Biol Chem 2002 : K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK
Hebron et al., Br J Haematol 2013 (Multiple Myeloma...) : In myeloma tumour cells, MAP3K8 acts as mitogen induced MAP3K in mitosis and is required for TNFa mediated ERK activation
Fan et al., J Biol Chem 1996 : Dual leucine zipper bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2
Hirai et al., J Biol Chem 1997 : Both MUK/DLK/ZPK and MST/MLK2 cause a slight activation of p38/Mpk2 when overexpressed in COS-1 cells, whereas MST/MLK2, but not MUK/DLK/ZPK , activates extracellular response kinase (ERK) to a certain degree