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NOS2 — SPP1

Text-mined interactions from Literome

Tian et al., Cytokine 2000 : Osteopontin has been shown to inhibit the induction of inducible nitric oxide synthase ( iNOS, or NOS2 ) by lipopolysaccharide and interferon-gamma in the RAW264.7 mouse monocyte/macrophage line and in primary mouse proximal tubule epithelial cells
Takahashi et al., IUBMB Life 2000 : OPN inhibits inducible nitric oxide synthase (iNOS) , which generates large amounts of NO production
Iczkiewicz et al., Brain Res Mol Brain Res 2004 : Osteopontin (OPN) is a secreted glycosylated phosphoprotein that is responsive to oxidative stress and inflammation and controls cytokine production, inducible nitric oxide synthase (iNOS) expression and apoptotic cell death
Wai et al., Surgery 2006 (Adenocarcinoma...) : OPN also inhibits expression of autocrine and paracrine inducible nitric oxide synthase (iNOS)
Guo et al., Surgery 2008 (Sepsis) : Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis ... Osteopontin (OPN) represses inducible nitric oxide synthase (iNOS) expression by increasing ubiquitin ( Ub ) -proteasome degradation of Stat1, a critical transcription factor for iNOS expression ... Exogenous OPN or MG132 restored Ub-P-Stat1 and iNOS to levels seen in WT
Zhang et al., Chin Med J (Engl) 2010 (Hyperoxia...) : OPN inhibits inducible nitric oxide synthase (iNOS) , which generates large amounts of nitric oxide production
Hwang et al., J Biol Chem 1994 : Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells ... The ability of OPN to inhibit the induction of iNOS suggests that OPN may be an important regulator of the NO signaling pathway and NO-mediated cytotoxic processes
Scott et al., Am J Physiol 1998 : Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue ... We tested the hypothesis that osteopontin (OPN) can inhibit the induction of inducible nitric oxide synthase (iNOS) in vascular tissue ... LPS resulted in an increase in iNOS protein and RNA, whereas OPN dose-dependently reduced tissue levels of iNOS activity, protein, and RNA ... Mutated OPN proteins, in which the integrin binding RGD amino acid sequence was deleted or mutated to RGE, resulted in complete and partial loss, respectively, of the ability of OPN to inhibit LPS induced iNOS activity, implicating integrin binding in the effect ... These results indicate that OPN can prevent induction of iNOS in vascular tissue