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CRK — ILK

Text-mined interactions from Literome

Leung-Hagesteijn et al., Mol Cell Biol 2005 : To investigate the role of ILK in BMP7 signaling, we showed that ILK overexpression increased basal and BMP7 induced levels of phospho-p38 ( MAPK ) and phospho-ATF-2 ... Consistent with its inhibitory effects on IMCD-3 cell morphogenesis, expression of ILK ( E359K ) blocked BMP7 dependent increases in phospho-p38 ( MAPK ) and phospho-ATF-2
Sawai et al., Oncogene 2006 (Disease Progression...) : Overexpressed ILK enhances the IL-1alpha induced p38 MAPK phosphorylation more strongly through glycogen synthase kinase 3 ( GSK-3 ) activation, and subsequently induces AP-1 activation, which promotes aggressive capabilities of pancreatic cancer cells