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BCL2 — NGF

Text-mined interactions from Literome

Liu et al., Nucleic Acids Res 1999 : Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade ... We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414
Riccio et al., Science 1999 : Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB dependent transcriptional mechanism
Groot et al., Eur J Cell Biol 2000 (Insulinoma...) : Likewise, NGF activated HES1 and Bcl2 P1 promoter activities in PC12 cells but not in INS-1 cells and EGF did not show any effects on these promoters
Bui et al., J Cell Biol 2001 : We investigated the effect of NGF on the expression of Bcl-xL , an anti-apoptotic Bcl-2 family protein ... NGF induced NFkappaB activity and Bcl-xL expression were inhibited in cells overexpressing the NFkappaB inhibitor, IkappaBalpha
Bui et al., J Neurochem 2002 (Pheochromocytoma) : We have previously shown that nerve growth factor (NGF) induced activation of nuclear factor-kappaB increased neuronal expression of Bcl-xL , an anti-apoptotic Bcl-2 family protein ... Treatment of hippocampal neurones with the blocking anti-p75 antibody inhibited constitutive and NGF induced Bcl-xL expression, activation of Akt, and blocked the protective effect of NGF against excitotoxic and apoptotic injury
Chiou et al., Anal Biochem 2007 : In sum, our data support that NGF prevents Fas induced apoptosis, facilitates neural differentiation, promotes dendritic formation, and increases DA release in PC12 cells through activation of Bcl-2
Zhang et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2011 (Burns...) : To explore the possible mechanism of nerve growth factor (NGF) mixed insulin on the angiogenesis of burn wounds and the effect on the expressions of Bcl-2 and Bax in diabetic rats
Horiuchi et al., J Biol Chem 1997 : Bcl-2 phosphorylation was stimulated by NGF , whereas AT2 receptor activation blocked this NGF effect
Schulz et al., J Neurochem 1997 : Forced expression of either BCL-2 or the BCL-2 binding protein BAG-1 blocked NGF withdrawal induced apoptosis, activation of caspases, and ROS generation, showing that they function upstream of caspases
Spear et al., Arch Biochem Biophys 1998 : Enhancement of peroxynitrite induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2