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CDC42 — EGF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nur-E-Kamal et al., Oncogene 1999
(Cell Transformation, Neoplastic) :
First of all, using the ACK42-GST fusion protein as a specific ligand for the GTP-CDC42 complex, we have revealed that
CDC42 is
activated by oncogenic Ras mutants such as v-Ha-Ras in NIH3T3 fibroblasts, and similarly in PC12 cells by both NGF ( Nerve Growth Factor ) and
EGF ( Epidermal Growth Factor ) which activate the endogenous normal Ras, providing the first direct evidence that CDC42 acts downstream of Ras and NGF/EGF
Gildea et al., Cancer Res 2002
(Neoplasm Metastasis...) :
Here we show that
EGF stimulates motility in human tumor cell lines, which harbor activating Ha-RasV12 via a novel signal transduction pathway mediated by the small GTP binding proteins RalA and RhoA but
independent of Rac1 and
Cdc42
Masuda-Robens et al., Mol Cell Biol 2003
:
Epidermal growth factor (EGF) induced relocalization of TRE17 to the plasma membrane in a
Cdc42-/Rac1 dependent manner
Wu et al., Cell 2003
(Cell Transformation, Neoplastic) :
Activated
Cdc42 sequesters c-Cbl and
prevents EGF receptor degradation
Tu et al., J Biol Chem 2003
:
The EGF dependent phosphorylation of Cdc42 occurs at tyrosine 64 in the Switch II domain and appears to be mediated through the Src tyrosine kinase, because both the expression of a dominant negative Src mutant ( mouse Src ( K297R ) ) and treatment of cells with the Src kinase inhibitor PP2 blocks the
EGF stimulated phosphorylation of
Cdc42 , whereas expression of an activated Src mutant ( Src ( Y529F ) ) promotes phosphorylation in the absence of EGF treatment ... The
EGF stimulated phosphorylation of
Cdc42 is not required for its activation, nor does it directly affect the interactions of activated Cdc42 with target/effector proteins including PAK, ACK, WASP, or IQGAP ... However, the
EGF stimulated phosphorylation of
Cdc42 is accompanied by an enhancement in the interaction of Cdc42 with the Rho-GDP dissociation inhibitor (RhoGDI) ... The
EGF stimulated activation of
Cdc42 does require activated Src, as well as the Vav2 protein, a member of the Dbl family of guanine nucleotide exchange factors
Huang et al., Cell Mol Life Sci 2005
:
In addition, emodin markedly suppressed
EGF induced activation of
Cdc42 and Rac1 and the corresponding cytoskeleton changes
Beier et al., Atherosclerosis 2008
:
However, the
effect of
EGF on
Rac/Cdc42 activation is unknown for VSMC ... In the present report, we evaluated
stimulation of
Rac/Cdc42 by
EGF in VSMC performing PAK-PBD binding assay
Schwarz et al., PloS one 2012
:
We previously reported about
EGF induced Ser-71 phosphorylation of
Rac1/Cdc42