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FOXO3 — MYC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated targets of C-MYC transcriptional repression: FOXO3A (FOXO3) → MYC/Max complex (MYC-MAX) (transcription, activates) Yang et al., Oncogene 2001*, Chandramohan et al., J Cell Biochem 2008*
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — FOXO3 (physical association, affinity chromatography technology) Chandramohan et al., J Cell Biochem 2008*

Text-mined interactions from Literome

Bouchard et al., EMBO J 2004 (Cell Transformation, Neoplastic) : Myc induced proliferation and transformation require Akt mediated phosphorylation of FoxO proteins
Gomis et al., Cancer Cell 2006 (Breast Neoplasms...) : We found the transcription factor C/EBPbeta to be essential for TGFbeta induction of the cell cycle inhibitor p15INK4b by a FoxO-Smad complex and repression of c-MYC by an E2F4/5-Smad complex in human epithelial cells
Bouchard et al., Genes Dev 2007 (Lymphoma) : Moreover, constitutive Myc signaling induces a marked increase in nuclear FoxO levels and stimulates binding of FoxO proteins to the Arf locus
Chandramohan et al., J Cell Biochem 2008 (Neoplasms) : The inhibition of FOXO3a mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype
Ferber et al., Cell Death Differ 2012 : Repression of these genes was mediated by FOXO3a dependent inhibition of c-Myc
Peck et al., Frontiers in oncology 2013 : Recent studies have revealed that FOXO3a acts as a negative regulator of mitochondrial function through inhibition of MYC