Gene interactions and pathways from curated databases and text-mining

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GNRH1 — SRC

Text-mined interactions from Literome

Harris et al., Endocrinology 2002 : Interestingly, the constitutively active form of c-Src stimulated the basal and the GnRH-A response, whereas the dominant negative form of c-Src , or the c-Src inhibitor PP1 diminished basal and the GnRH-A response
Shah et al., J Biol Chem 2003 (MAP Kinase Signaling System) : GnRH stimulation caused translocation of PKC alpha and -epsilon to the cell membrane and enhanced the association of Src with PKC alpha and PKC epsilon, Pyk2, and the EGF receptor
Harris et al., Endocrinology 2003 : Thus, ERK and c-Src but not JNK are involved in basal and GnRH-A-stimulated-alphaCAT , whereas c-Src contribution is independent of ERK activation
Roelle et al., J Biol Chem 2003 (MAP Kinase Signaling System) : We found that GnRH induced Src , Ras, and ERK activation were also gelatinase dependent
Davidson et al., J Biol Chem 2004 : Using matrix assisted laser desorption ionization time-of-flight mass spectrometry we identified a GnRH induced association between c-Src and the lipid kinase, diacylglycerol kinase-zeta (DGK-zeta)
Bonfil et al., Endocrinology 2004 : Extracellular signal regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin releasing hormone stimulated activity of the glycoprotein hormone follicle stimulating hormone beta-subunit promoter ... Thus, PKC, ERK, JNK, p38, and c-Src , but not Ca ( 2+ ), are involved in GnRH induction of the ovine FSHbeta gene
Maudsley et al., Neuroendocrinology 2006 : GnRH induced c-Src activation resulted in the phosphorylation of expressed Hic-5 and promoted its association with the human androgen receptor
Maudsley et al., Mol Endocrinol 2007 : We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2
Levi et al., Mol Endocrinol 1998 : GnRH as well as tumor promoting agent ( TPA ) also increased c-Src activity, which peaked at 2 min after GnRH stimulation and was sensitive both to PKC and to tyrosine kinase inhibitors