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Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Remarkably, leptin induces a greater increase in VEGF/VEGFR2 and LIF levels in cancer than in benign cells
Guo et al., PloS one 2011 (Mammary Neoplasms, Animal) : Notch, IL-1 and leptin crosstalk outcome ( NILCO ) is critical for leptin induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer ... We have previously reported that leptin induces the growth of breast cancer and the expression of VEGF/VEGFR-2 and IL-1 system ... To test this hypothesis, leptin 's effects on the expression and activation of Notch signaling pathway and VEGF/VEGFR-2/IL-1 were determined in mouse ( 4T1, EMT6 and MMT ) breast cancer cells ... In addition, blockade of IL-1R tI inhibited leptin induced Notch, Hey2 and survivin as well as VEGF/VEGFR-2 expression ... These data suggest leptin is an inducer of Notch ( expression/activation ) and IL-1 signaling modulates leptin effects on Notch and VEGF/VEGFR-2