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CD40 — FAS

Text-mined interactions from Literome

Hsing et al., J Immunol 1999 : Surprisingly, up-regulation of Fas , CD23, and ICAM-1 was partially independent, and up-regulation of LFA-1 was completely independent , of CD40 induced NF-kappaB activation
Fujieda et al., Oncol Res 1998 (Carcinoma...) : CD40 stimulation enhanced Fas expression on HTC/C3 cells
Decker et al., Blood 2000 (Leukemia, Lymphocytic, Chronic, B-Cell) : In contrast, CD95 expression induced by CD40-ligation was inhibited by CpG-ODN
Servet-Delprat et al., J Virol 2000 : A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through Fas mediated apoptosis and CD40 activation of DCs
Holub et al., Eur J Gastroenterol Hepatol 2003 (Carcinoma, Hepatocellular...) : CD40 ligation had no effect on cell viability or surface expression of CD54, CD80, CD86 or CD95
de Totero et al., Haematologica 2003 (Leukemia, Lymphocytic, Chronic, B-Cell) : CD40 triggering, however, rescues CLL B-cells from their anergic state and upregulates the FAS receptor
Yamaguchi et al., Int J Oncol 2003 (Carcinoma...) : Stimulation of CD40 inhibits Fas- or chemotherapy mediated apoptosis and increases cell motility in human gastric carcinoma cells
Benson et al., Eur J Immunol 2006 : CD40 signaling increases CD95 expression, sensitizing cells to apoptosis, but sustained CD40 signals rescue B cells from CD95 killing ... CD40 signaling did not block association of Fas associated death domain containing protein with CD95 , but decreased CD95 induced activation of caspases 3 and 8
Troeger et al., Blood 2007 (Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) : However, even though CD40 ligation results in up-regulation of CD95 , ALL blasts, unlike normal B cells, remain resistant to apoptosis
Waid et al., J Leukoc Biol 2008 (Diabetes Mellitus) : CD40 engagement of Th40 cells induces Fas expression but further confers resistance to Fas mediated cell death in NOD mice
Mavroudi et al., J Leukoc Biol 2011 (Leukemia, Myeloid, Acute...) : CD40 activation in primary as wells as in KG-1 cells resulted in Fas up-regulation, providing a mechanism for the CD40 mediated apoptosis
Lens et al., J Immunol 1996 (Burkitt Lymphoma) : In contrast to the strong effect of BCR ligation, APO-1 mAb induced apoptosis in only +/- 18 % of the Ramos cells after 48 h. Noticeably, addition of CD40 mAb or rTNF-alpha increased the percentage of cells ( +/- 46 % ) undergoing apoptosis, which correlated with an increase of Fas/APO-1 membrane expression induced by CD40 or TNF-R ligation
Galibert et al., J Exp Med 1996 : CD40 + BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies resulted in the coexpression of CD38, CD95 , and CPM
Nakanishi et al., Int Immunol 1996 : Furthermore we showed that stimulation of B cells with anti-CD40 induced the expression of Fas molecules on the B cells ( approximately 30 % ) and rendered them highly sensitive to anti-Fas mediated apoptotic cell death
Schattner et al., Blood 1996 (Burkitt Lymphoma) : Recent studies using nontransformed B cells and the Ramos Burkitt 's lymphoma ( BL ) B-cell line cells show that CD40 ligation at the B-cell surface by activated, CD40 ligand (CD40L) bearing, CD4+ T cells upregulates Fas expression on B cells and primes B cells for Fas mediated death signals ... All 6 of the BL cell line B cells upregulate Fas in response to CD40 ligation, and in 4 of the cases they become sensitive to Fas mediated death signals
Kehry et al., J Immunol 1996 : CD40 mediated signaling also regulates cell death, rescuing B cells from anti-Ig induced apoptosis and inducing the expression of the Fas surface molecule
Schattner et al., Immunol Res 1996 : In the course of cognate interaction between CD40 ligand (CD40L) bearing CD4+ T cells and CD40 expressing germinal center B cells, CD40 ligation results in augmented Fas expression at the B cell surface
Hsing et al., J Immunol 1997 (Lymphoma, B-Cell) : However, NF-kappa B activation was insufficient for CD40 mediated up-regulation of B7-1, Fas , and CD23
Alam et al., Eur J Immunol 1997 (Burkitt Lymphoma) : In addition, following up-regulation of the Fas ( CD95 ) surface receptor by CD40 ligation, these cells also become susceptible to apoptosis induction by Fas ligation
Foote et al., J Exp Med 1998 : Engagement of CD40 led to enhanced Fas expression and acquisition of sensitivity to Fas mediated apoptosis in tolerant B cells, similar to that observed in nontolerant, receptor transgenic B cells
Plumas et al., Blood 1998 (Lymphoma, Non-Hodgkin) : Concerning malignant B cells, CD40 ligation in the presence of IL-4 strongly increased CD95 expression, but did not markedly increase CD95 induced apoptosis
Goldstein et al., J Immunol 1997 : In contrast, the expression of the PKA-R ( G324D ) subunit has no effect on CD40 mediated growth inhibition in M12 cells, nor on CD40 mediated induction of B7-1, CD23, Fas , ICAM-1, or LFA-1
Xerri et al., Br J Cancer 1998 (Lymphoma, B-Cell) : Activation of neoplastic B cells by CD40 ligation resulted in significant increases in Fas expression and Fas induced apoptosis among the five B-NHL cases tested
Craxton et al., J Immunol 1998 (Lymphoma, B-Cell) : In addition, SB203580 selectively reduced CD40 induced CD54/ICAM-1 expression, whereas CD40 dependent expression of CD40 and CD95/Fas and four newly defined CD40-responsive genes cIAP2, TRAF1, TRAF4/CART and DR3 were unaffected