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CXCL12 — JAK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → FAK (PTK2) (modification, activates) Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → p130 Cas (BCAR1) (modification, activates) Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → G beta/gamma complex (GNB1-GNG2) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Paxillin (PXN) (modification, activates) Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → JAK2 (JAK2) (modification, collaborate) Vila-Coro et al., FASEB J 1999, Ahr et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → SDF1/CXCR4 complex (CXCL12-CXCR4) (modification, collaborate)
  Vila-Coro et al., FASEB J 1999, Ahr et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: JAK2 (JAK2) → SDF1/CXCR4 complex (CXCL12-CXCR4) (modification, collaborate)
  Vila-Coro et al., FASEB J 1999, Ahr et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → STAT2 (STAT2) (modification, activates) Vila-Coro et al., FASEB J 1999, Zhang et al., Blood 2001
  Evidence: assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → PI3K Class I family (PIK3CA/PIK3R1/PIK3CB/PIK3R1/PIK3CG/PIK3R6) (modification, activates)
  Zhang et al., Blood 2001
  Evidence: assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: STAT1-3-5 (STAT5A/STAT5B/STAT1/STAT3) → SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) (modification, collaborate)
  Vila-Coro et al., FASEB J 1999, Ahr et al., J Biol Chem 2005
  Evidence: assay, physical interaction

Text-mined interactions from Literome

Moriguchi et al., J Biol Chem 2005 : CXCL12 signaling is independent of Jak2 and Jak3
Lee et al., Int J Biochem Cell Biol 2007 (MAP Kinase Signaling System) : The OSM stimulated expression of SDF-1 in hATSCs was completely abrogated by pretreatment of the cells with U0126, an MEK-specific inhibitor, but not with AG490, a JAK2 inhibitor, or WHI-P131, a JAK3 inhibitor, suggesting that ERK, but not JAK2 and JAK3, is involved in the OSM induced expression of SDF-1
Gao et al., Stem Cells 2009 : Impaired MSC migration correlated with decreased levels of phosphorylated STAT3 and ERK1/2, suggesting that SDF-1 stimulation activates Jak2/STAT3 as well as MEK/ERK1/2 signaling, which in turn promotes migration of MSCs toward tumor cells