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IKBKG — PLK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PLK1 — IKBKG (physical association, affinity chromatography technology) Zhang et al., Mol Biol Cell 2010*

Text-mined interactions from Literome

Higashimoto et al., J Biol Chem 2008 : Expressing a constitutively active Plk1 in mammalian cells reduced tumor necrosis factor (TNF) induced IKK activation, resulting in decreased phosphorylation of endogenous IkappaBalpha and reduced NF-kappaB activation ... Knocking down Plk1 in mammalian cells restored TNF induced IKK activation in nocodazole treated cells
Zhang et al., Mol Biol Cell 2010 : We describe a new regulatory mechanism for PLK1 : PLK1 negatively regulates TNF induced IKK activation by inhibiting the ubiquitination of NEMO