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BCR — PLCG1

Pathways - manually collected, often from reviews:

• Reactome Reaction: BCR → PLCG1 (reaction) Carpenter et al., Exp Cell Res 1999, Guasch et al., Mol Cell Biol 2001, Roumiantsev et al., Cancer Cell 2004, Chase et al., Blood 2007, Lelièvre et al., Molecular cancer 2008
• Reactome Reaction: BCR → PLCG1 (indirect_complex) Guasch et al., Mol Cell Biol 2001, Roumiantsev et al., Cancer Cell 2004, Chase et al., Blood 2007, Lelièvre et al., Molecular cancer 2008

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: PLCG1 — BCR (affinity chromatography technology) Muller et al., Mol Cell Biol 1992
• IRef Hprd Interaction: BCR — PLCG1 (in vitro) Muller et al., Mol Cell Biol 1992
• IRef Ophid Interaction: BCR — PLCG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

DeBell et al., Mol Cell Biol 1999 : B-cell receptor (BCR) induced activation of phospholipase C-gamma1 ( PLCgamma1 ) and PLCgamma2 is crucial for B-cell function ... The role of PLCgamma1 SH2 and SH3 domains at different steps of BCR induced PLCgamma1 activation was examined by reconstitution in a PLCgamma negative B-cell line ... PLCgamma1 SH domains, therefore, have interrelated but distinct roles in BCR induced PLCgamma1 activation
Che et al., Circulation 2001 : Because phosphatidylinositol 3'-kinase (PI3-K) is essential for Bcr/Abl leukemogenesis, we evaluated the role of mouse PDGF-beta-receptor binding sites for PI3-K ( Y708, Y719 ) and for phospholipase C-gamma ( Y977, Y989 ) in PDGF mediated Bcr kinase activation
Venkataraman et al., Mol Immunol 1998 : Previous studies have shown that PKA-activation blocks BCR induced phospholipase Cgamma-activation and calcium mobilization