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CREB5 — MAPKAPK2
Text-mined interactions from Literome
Miguel et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
These data define a novel mitogenic signaling pathway in osteoblasts whereby ERK1/2 stimulation of
CREB phosphorylation and transcriptional activity as well as DNA synthesis are critically
dependent on de novo
Mapkapk2 synthesis
Tan et al., EMBO J 1996
:
We show that MAPKAP kinase-2 phosphorylates CREB at Ser133 in vitro, that the FGF- or stress induced
activation of
MAPKAP kinase-2 and phosphorylation of
CREB and ATF-1 are prevented by similar concentrations of the specific p38 MAP kinase inhibitor SB 203580, and that MAPKAP kinase-2 is the only detectable SB 203580-sensitive CREB kinase in SK-N-MC cell extracts