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MUC2 — SP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MUC2 → SP1 (directlyIncreases, MUC2 Activity) Perrais et al., J Biol Chem 2002*
  Evidence: Sp1 binds and transactivates Muc2 and Muc5ac promoters. Inhibition of Sp1 binding by mithramycin A reduced Muc2 mRNA and to a smaller level, reduced Muc5ac mRNA.

Text-mined interactions from Literome

Perrais et al., J Biol Chem 2002 (Carcinoma, Squamous Cell...) : Finally, we demonstrate that transcription factor Sp1 not only binds and activates MUC2 and MUC5AC promoters but also participates to their EGF- and TGF-alpha mediated up-regulation
Jonckheere et al., Biochem J 2004 (Neoplasms, Glandular and Epithelial) : Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1