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CNTN2 — TNF
Text-mined interactions from Literome
Twizere et al., J Natl Cancer Inst 2003
(Neoplasms) :
Tax , through its interactions with the TTP repressor, indirectly
increases TNF-alpha expression
Alefantis et al., J Biol Chem 2005
(Necrosis...) :
However, it is also known that extracellular
Tax induces the production and release of cytokines, such as
tumor necrosis factor-alpha and interleukin-6, which have adverse effects on cells of the central nervous system
Hong et al., J Biol Chem 2007
:
Interestingly, peptides spanning CCR2 and/or LZ disrupt
IKKgamma-Tax and IKKgamma-PP2A interactions and potently
inhibit NF-kappaB activation by Tax and
tumor necrosis factor-alpha
Dhib-Jalbut et al., Ann Neurol 1994
:
Tax ( 20 ng/ml )
induced TNF-alpha in microglia ( from undetectable or low basal levels to 215-1,075 pg/ml, mean 576 +/- 375 pg/ml, n = 4 ) and in PBMs ( 70-1,900, mean 646 +/- 844 pg/ml, n = 4 )
Chlichlia et al., Oncogene 1997
:
Both APO ( S ) and APO ( R ) clones exhibited
Tax dependent upregulation of CD95 ligand and
TNF-alpha