◀ Back to TNF
GSTM3 — TNF
Text-mined interactions from Literome
Mangalam et al., Int Immunopharmacol 2001
:
We studied the
effect of
GSTM on spontaneous and LPS stimulated
TNF-alpha production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers ...
GSTM stimulated spontaneous TNF-alpha production and
inhibited LPS stimulated
TNF-alpha production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group ... We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS, and
GSTM inhibits LPS stimulated
TNF-alpha production, primarily in LPS responders
Kumar Mangalam et al., Cell Immunol 2002
:
We have previously shown that
GSTM , an anti-rheumatic drug
inhibits LPS stimulated
TNF-alpha production by normal PBMCs ... Thus, we for the first time report that
GSTM inhibits LPS stimulated
TNF-alpha production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production
Yadav et al., Int J Immunopharmacol 1997
(Arthritis, Rheumatoid) :
GSTM and MTX
augmented spontaneous
TNF alpha production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production ... These data indicate that
GSTM can
inhibit TNF alpha production when the PBMC are preactivated by LPS