◀ Back to TP53
TP53 — TSC2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Feng et al., Cancer Res 2007
(Cell Transformation, Neoplastic) :
The
regulation of AMPK beta1,
TSC2 , and PTEN expression by
p53 : stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
Lee et al., EMBO J 2007
(Hamartoma...) :
Thus, loss of TSC1 or
TSC2 , the negative regulators of mTOR,
results in dramatic accumulation of
p53 and apoptosis in response to stress conditions