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CCNA2 — CDK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDK2 → Complex of CCNA2-CDK2 (directlyIncreases, CCNA2/CDK2 Activity)
  Evidence: E2 sensitivity is regulated by acetylation of lysines 302 and 303, by CREB-binding protein (CBP).
• OpenBEL Selventa BEL large corpus: CDK2 → CCNA2 (directlyIncreases, CCNA2 Activity)
  Evidence: P53 is phosphorylated at Ser315 by CycA:Cdk2 and by CycB:Cdc2
• OpenBEL Selventa BEL large corpus: CDK2 → CCNA2 (directlyIncreases, CCNA2 Activity)
  Evidence: CCNA2 CDK2=^E2F1{P@?} CNA2 CDK2=^E2F2{P@?} CCNA2 CDK2=^E2F3{P@?}
• KEGG Cell cycle: Complex of CCNA1-CCNA2-CDK2 → CDC6 (protein-protein, inhibition)
• KEGG Cell cycle: CDKN1B/CDKN1C → Complex of CCNA1-CCNA2-CDK2 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN1A → Complex of CCNA1-CCNA2-CDK2 (protein-protein, inhibition)
  
• KEGG Cell cycle: Complex of CCNA1-CCNA2-CDK2 → RB1 (protein-protein, inhibition)
• KEGG Cell cycle: Complex of CCNA1-CCNA2-CDK2 → E2F1/E2F2/E2F3 (protein-protein, inhibition)
• NCI Pathway Database p73 transcription factor network: Cyclin A/CDK1-2 complex (CCNA2-CDK1_CDK2) → TAp73b (tetramer) complex (TP73) (modification, activates)
  Gaiddon et al., J Biol Chem 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin A complex (CDK2-CCNA2) → RB1/c-Abl complex (RB1-ABL1) (modification, activates)
  Welch et al., Cell 1993*, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATR signaling pathway: CDK2/Cyclin A complex (CDK2-CCNA2) → ATR/ATRIP complex (ATR-ATRIP) (modification, activates)
  Myers et al., Cancer Res 2007*
  Evidence: mutant phenotype, assay
• NCI Pathway Database FOXM1 transcription factor network: RB1/FOXM1C complex (FOXM1-RB1) → Cyclin A-E1/CDK1-2 complex (CCNA2_CCNE1-CDK2) (modification, collaborate)
  Lüscher-Firzlaff et al., FEBS Lett 2006, Wierstra et al., Biochem Biophys Res Commun 2006, Wierstra et al., Biol Chem 2006
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database p53 pathway: CDK2/Cyclin A complex (CDK2-CCNA2) → JNK1-2-active (MAPK8/MAPK9) (modification, activates)
  Bulavin et al., EMBO J 1999*, Blaydes et al., J Biol Chem 2001*, Buschmann et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: CDK2/Cyclin A complex (CDK2-CCNA2) → p38 alpha (MAPK14) (modification, activates) Bulavin et al., EMBO J 1999*, Blaydes et al., J Biol Chem 2001*, Buschmann et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by PRL: Cyclin A (CCNA2) → CDK2/Cyclin E1 complex (CDK2-CCNE1) (G1/S transition of mitotic cell cycle, collaborate)
  
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin A complex (CDK2-CCNA2) → RB1 (RB1) (modification, activates) Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin A complex (CDK2-CCNA2) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Davies et al., Nat Struct Biol 2002*, Lowe et al., Biochemistry 2002*, Hardcastle et al., J Med Chem 2004*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Cook et al., Biochemistry 2002*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Davies et al., Structure 2001*
• IRef Bind Interaction: CCNA2 — CDK2 Davis et al., Science 2001*
• IRef Bind Interaction: CCNA2 — CDK2 Andrews et al., Org Biomol Chem 2004*
• IRef Bind Interaction: CCNA2 — CDK2
• IRef Bind Interaction: CCNA2 — CDK2 Sayle et al., Bioorg Med Chem Lett 2003*
• IRef Bind Interaction: CCNA2 — CDK2 Russo et al., Nature 1996*
• IRef Bind Interaction: CCNA2 — CDK2 Jeffrey et al., Nature 1995*
• IRef Bind Interaction: CCNA2 — CDK2 Pevarello et al., J Med Chem 2005*
• IRef Bind Interaction: CCNA2 — CDK2 Russo et al., Nat Struct Biol 1996*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Cook et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Davies et al., Nat Struct Biol 2002*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*, Kontopidis et al., Structure 2003*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Johnson et al., Pharmacol Ther 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Davies et al., Nat Struct Biol 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
• IRef Bind Interaction: CCNA2 — CDK2 Brown et al., Nat Cell Biol 1999*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Andrews et al., Org Biomol Chem 2004*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (coimmunoprecipitation) Laman et al., EMBO J 2005
• IRef Bind_translation Interaction: CCNA2 — CDK2 (coimmunoprecipitation) Orend et al., Oncogene 1998
• IRef Bind_translation Interaction: CCNA2 — CDK2 (coimmunoprecipitation) Poon et al., J Biol Chem 1996
• IRef Bind_translation Interaction: CCNA2 — CDK2 (coimmunoprecipitation) Ji et al., Mol Cell 2004
• IRef Bind_translation Interaction: CCNA2 — CDK2 (coimmunoprecipitation) Sebastian et al., Proc Natl Acad Sci U S A 1993*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Pevarello et al., J Med Chem 2005*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Jeffrey et al., Nature 1995*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography)
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Russo et al., Nat Struct Biol 1996*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Russo et al., Nature 1996*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*, Hardcastle et al., J Med Chem 2004*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*, Davies et al., Nat Struct Biol 2002*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Davis et al., Science 2001*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Davies et al., Structure 2001*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Davies et al., Nat Struct Biol 2002*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Johnson et al., Pharmacol Ther 2002*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Sayle et al., Bioorg Med Chem Lett 2003*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Pevarello et al., Bioorg Med Chem Lett 2006*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Richardson et al., Bioorg Med Chem Lett 2006*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*, Kontopidis et al., Structure 2003*
• IRef Bind_translation Interaction: CCNA2 — CDK2 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Abbas et al., Cell cycle (Georgetown, Tex.) 2007*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Schulman et al., Proc Natl Acad Sci U S A 1998*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Datta et al., Cell Growth Differ 1998
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Wu et al., Oncogene 1997*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Sebastian et al., Proc Natl Acad Sci U S A 1993*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Liu et al., Cancer Lett 2009*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Ciarallo et al., Mol Cell Biol 2002*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Wolthuis et al., Mol Cell 2008
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Vicent et al., Genes Dev 2011*
• IRef Biogrid Interaction: CCNA2 — CDK2 (direct interaction, pull down) Zhang et al., Cell 1995*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Sayle et al., Bioorg Med Chem Lett 2003*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Jeffrey et al., Nature 1995*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Davies et al., Structure 2001*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Cook et al., Biochemistry 2002*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Pevarello et al., Bioorg Med Chem Lett 2006*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Levkau et al., Mol Cell 1998*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Poon et al., J Biol Chem 1996
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) O'Connor et al., J Biol Chem 1993*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Davies et al., Nat Struct Biol 2002*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Kontopidis et al., Structure 2003*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Andrews et al., Org Biomol Chem 2004*
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Pevarello et al., J Med Chem 2004*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Biogrid Interaction: CCNA2 — CDK2 (association, x-ray crystallography) Pevarello et al., J Med Chem 2005*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Henneke et al., Oncogene 2003*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Naderi et al., Mol Biol Cell 2005*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Varshochi et al., J Biol Chem 2005*
• IRef Biogrid Interaction: CCNA2 — CDK2 (direct interaction, enzymatic study) Mateo et al., Oncogene 2009*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Di Fiore et al., J Cell Biol 2010*
• IRef Biogrid Interaction: CCNA2 — CDK2 (physical association, affinity chromatography technology) Mateo et al., Nucleic Acids Res 2009*
• MIPS CORUM RC complex (Replication competent complex): RC complex (Replication competent complex) complex (CCNA2-CDK2-POLA1-POLA2-RFC1-RFC2-RFC3-RFC4-RFC5) Frouin et al., EMBO J 2002
• MIPS CORUM RC complex during S-phase of cell cycle: RC complex during S-phase of cell cycle complex (CCNA2-CDK2-LIG1-PARP1-POLA1-POLD1-POLE-RFC1-RFC2-RPA1-RPA2-RPA3-TOP1) Frouin et al., EMBO J 2002
• MIPS CORUM CDK2-CCNA2 complex: CDK2-CCNA2 complex complex (CCNA2-CDK2) Sebastian et al., Proc Natl Acad Sci U S A 1993*
• MIPS CORUM CDC2-CCNA2-CDK2 complex: CDC2-CCNA2-CDK2 complex complex (CCNA2-CDK1-CDK2) Rohaly et al., Cell 2005*
• IRef Corum Interaction: Complex of 40 proteins (association, anti bait coimmunoprecipitation) Frouin et al., EMBO J 2002
• IRef Corum Interaction: CCNA2 — CDK2 (association, coimmunoprecipitation) Sebastian et al., Proc Natl Acad Sci U S A 1993*
• IRef Corum Interaction: Complex of CCNA2-CDK1-CDK2 (association, coimmunoprecipitation) Rohaly et al., Cell 2005*
• IRef Corum Interaction: Complex of 19 proteins (association, cosedimentation through density gradient) Frouin et al., EMBO J 2002
• IRef Dip Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Jeffrey et al., Nature 1995*
• IRef Dip Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Davies et al., Nat Struct Biol 2002*
• IRef Dip Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Brown et al., Nat Cell Biol 1999*
• IRef Dip Interaction: CCNA2 — CDK2 (direct interaction, coimmunoprecipitation) Koundrioukoff et al., J Biol Chem 2000*
• IRef Hprd Interaction: Complex of CDK2-CCNA2-E2F3-CCNA2-CDK2-E2F3-E2F3-CDK2-CCNA2 (in vivo) Dynlacht et al., Mol Cell Biol 1997
• IRef Hprd Interaction: CCNA2 — CDK2 (in vitro) Arooz et al., Biochemistry 2000*, Jackman et al., Mol Biol Cell 2002*
• IRef Hprd Interaction: CCNA2 — CDK2 (in vivo) Arooz et al., Biochemistry 2000*, Jackman et al., Mol Biol Cell 2002*
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Leng et al., Mol Cell Biol 2002
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Ruffner et al., Mol Cell Biol 1999*, Wang et al., Oncogene 1997
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Dynlacht et al., Mol Cell Biol 1997
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Xu et al., Mol Cell Biol 1994*
• IRef Hprd Interaction: Complex of CDK2-CCNA2-CDKN1B-CDK2-CCNA2-CCNA2-CDKN1B-CDKN1B-CDK2 (in vivo) Grimmler et al., Cell 2007*, Russo et al., Nature 1996*
• IRef Intact Interaction: Complex of CDKN1A-CDK2-CCNA2 (physical association, surface plasmon resonance) Lacy et al., J Mol Biol 2005*
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Davis et al., Science 2001*
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Davies et al., Nat Struct Biol 2002*
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Sayle et al., Bioorg Med Chem Lett 2003*
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Pevarello et al., J Med Chem 2004*
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Hardcastle et al., J Med Chem 2004*
• IRef Intact Interaction: CCNA2 — CDK2 (direct interaction, x-ray crystallography) Russo et al., Nat Struct Biol 1996*
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of CDK2-RBX1-CDKN1B-SKP1-SKP2-CKS1B-CCNA2-CUL1 (association, molecular sieving) Hao et al., Mol Cell 2005
• IRef Intact Interaction: Complex of 25 proteins (physical association, x-ray crystallography) Russo et al., Nature 1996*
• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of SKP2-CCNA1-CDK2-CCNA2-CDK1-CDT1 (association, coimmunoprecipitation) Sugimoto et al., J Biol Chem 2004
• IRef Intact Interaction: Complex of CCNA2-CDK2-CDKN1B (phosphorylation reaction, protein kinase assay) Grimmler et al., Cell 2007*
• IRef Intact Interaction: Complex of 14 proteins (association, anti bait coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of CCNA2-CCNA1-ORC1-CDK2-ORC2 (association, coimmunoprecipitation) Méndez et al., Mol Cell 2002
• IRef Ophid Interaction: CCNA2 — CDK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bártová et al., Protein Sci 2004 : Nanoseconds long molecular dynamics ( MD ) trajectories of differently active complexes of human cyclin dependent kinase 2 ( inactive CDK2/ATP , semiactive CDK2/Cyclin A/ATP, fully active pT160-CDK2/Cyclin A/ATP, inhibited pT14- ; pY15- ; and pT14,pY15,pT160-CDK2/Cyclin A/ATP ) were compared
De Vivo et al., Proteins 2006 : The enzymatic activity of the CDK2/Cyclin A complex increases upon the specific phosphorylation of Thr160 @ CDK2
Xu et al., J Biol Chem 2007 : p27 , an important cell cycle regulator, blocks the G ( 1 ) /S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes (Cdk2/E)
Maddika et al., J Cell Sci 2008 : Although CDK2 threonine 39 phosphorylation mediated by Akt enhances cyclin-A binding, it is dispensable for its basal binding and the kinase activity
Chae et al., BMB Rep 2011 : We previously reported that CDK2/Cyclin A can phosphorylate and activate the transcription factor NF-Y ... Furthermore, expression of Cyclin A increases NF-Y 's affinity for CCAAT sequences in the CDC2 promoter ; however, Cyclin A 's induction of CDC2 transcription is antagonized by p21 , an inhibitor of CDK2/Cyclin A
Shehata et al., Cell Signal 2012 : We hypothesised that cyclin Y binds and activates PCTAIRE-1 in a way similar to which cyclin A2 binds and activates CDK2
Connell-Crowley et al., Mol Biol Cell 1993 : To determine if the Cdk2/cyclin A complex could be activated further by phosphorylation of T160 , complexes were treated with Cdc2 activating kinase (CAK), purified approximately 12,000-fold from Xenopus eggs