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AGTR2 — RHOA

Text-mined interactions from Literome

Andresen et al., American journal of physiology. Renal physiology 2005 (Hypertension, Renal) : Therefore, our data indicate that AT(2) receptors activate Galpha ( i ), subsequently stimulating NO synthase and leading to increased soluble guanylyl cyclase activity, generation of cGMP, and activation of a protein kinase, resulting in phosphorylation of RhoA on serine 188 ... Furthermore, because AT(2) receptors inhibit AT(1) receptor signaling to PLD via modulating RhoA activity, AT(2) receptor signaling can potentially regulate multiple vasoconstrictive signaling systems through inactivating RhoA
Savoia et al., J Hypertens 2005 (Hypertension...) : Ang II/AT2R negatively regulates vascular RhoA/Rho kinase/MLC phosphorylation
Guilluy et al., Circ Res 2008 (Hypertension) : Here we show that stimulation of angiotensin II (Ang II) type 2 receptor ( AT(2)R ) in vascular smooth muscle cells induces Ser188 phosphorylation of RhoA independently of cAMP- or cGMP activated kinase