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E2F1 — SERPINE1

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → PAI-1 (SERPINE1) (transcription, inhibits) Koziczak et al., Mol Cell Biol 2000
  Evidence: mutant phenotype, reporter gene

Text-mined interactions from Literome

Koziczak et al., Mol Cell Biol 2000 : We found that overexpression of E2F1-3 , which acts mainly in late G ( 1 ), inhibits promoter activity and endogenous expression of the urokinase-type PA (uPA) and PA inhibitor 1 (PAI-1) genes ... Interestingly, an E2F1 mutant lacking the pRB binding region strongly repressed the uPA and PAI-1 promoters
Venugopal et al., J Cell Biochem 2007 : Depletion of E2F1-3 was sufficient for inducers such as insulin to potently induce PAI-1 gene expression in pre-adipocytes ... Conversely, forced release of pRB bound endogenous E2F using cell penetrating peptides can suppress PAI-1 gene expression in adipocytes