Maeda et al., J Biol Chem 2006
:
Unexpectedly, PP1 prevented Smad2/3 activation by TGF-beta1, whereas SU6656 did not
Ungefroren et al., Curr Cancer Drug Targets 2011
:
Likewise, PP2 and PP1 but not SU6656 effectively blocked TGF-ß1 induced activation of Smad2 and p38 MAPK and partially suppressed Smad activation and transcriptional activity on TGF-ß/Smad-responsive reporters of a kinase-active TßRI mutant ectopically expressed in Panc1 cells