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CTNNB1 — PTEN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Persad et al., J Cell Biol 2001
:
Mechanistically,
PTEN increases the phosphorylation of
beta-catenin and enhances its rate of degradation ... We define a pathway that involves mainly integrin linked kinase and glycogen synthase kinase 3 in the
PTEN dependent regulation of
beta-catenin stability, nuclear beta-catenin expression, and transcriptional activity
Sharma et al., J Biol Chem 2002
(Prostatic Neoplasms) :
Using the mutants of beta-catenin, we further demonstrate that the repressive effect of
PTEN is
mediated by a GSK3beta regulated degradation of
beta-catenin
Vogelmann et al., J Cell Sci 2005
:
By contrast, forced expression of
PTEN clearly
reduced the TGFbeta(1) induced phosphorylation of
beta-catenin
Zhang et al., Stem Cells 2006
(Neoplasms) :
Subsequently,
PTEN , through phosphatidyl inositol 3-kinase-Akt,
inhibits the activity of
beta-catenin , the convergence point of the BMP and Wnt signaling pathways
Hays et al., In Vitro Cell Dev Biol Anim 2009
:
Beta-catenin is not
activated by downregulation of
PTEN in osteoblasts
Humtsoe et al., Mol Cell Biol 2010
:
Thus, our study identified a key role for LPP3 in orchestrating
PTEN mediated
beta-catenin/LEF-1 signaling in EC migration, cell-cell adhesion, and formation of branching point structures