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CASP10 — GATA1
Text-mined interactions from Literome
De Maria et al., Nature 1999
:
Negative regulation of erythropoiesis by
caspase mediated cleavage of
GATA-1 ... Exposure of erythroid progenitors to mature erythroblasts or death-receptor ligands resulted in
caspase mediated degradation of the transcription factor
GATA-1 , which is associated with impaired erythroblast development ... Expression of a caspase-resistant GATA-1 mutant, but not of the wild-type gene, completely restored erythroid expansion and differentiation following the triggering of death receptors, indicating that there is regulatory feedback between mature and immature erythroblasts through
caspase mediated cleavage of
GATA-1
Zeuner et al., Blood 2006
(Polycythemia Vera) :
JAK2 mutated PV erythroblasts showed lower levels of CD95 induced caspase activation and incomplete
caspase mediated cleavage of the erythroid transcription factor
GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation
Ribeil et al., Nature 2007
:
Hsp70 regulates erythropoiesis by preventing
caspase-3 mediated cleavage of
GATA-1
Sztiller-Sikorska et al., Br J Pharmacol 2009
:
Binding activity of
GATA-1 , transcription factor responsible for differentiation and cell survival, was not
diminished by increased
caspase-3 activity during drug stimulated differentiation