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PPP2CA — SRC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yokoyama et al., FEBS Lett 2001
:
Addition of okadaic acid, a PP2A phosphatase inhibitor, abolished the
PP2A dependent inhibition of
v-Src ... These results imply that
PP2A activity is
essential for inhibition of
v-Src
Hu et al., BMC neuroscience 2009
(Brain Ischemia...) :
Ischemia induced
Src activation is
followed by phosphorylation of
PP2A at Tyr307 leading to its inhibition in the rat hippocampus
Nho et al., J Biol Chem 2011
:
The inhibition of
Src activity dramatically
increases PP2A and 4EBP-1 expression
Switzer et al., Mol Cancer Res 2012
:
NO, at physiologically relevant concentrations, induced an
EGFR/Src mediated activation of oncogenic signal transduction pathways ( including c-Myc, Akt, and ß-catenin ) and the loss of
PP2A tumor suppressor activity
Xiong et al., Neurobiol Aging 2013
(Tauopathies) :
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through
Src dependent
PP2A ( tyrosine 307 ) phosphorylation
Gupta et al., Biochem Biophys Res Commun 1994
:
We report here that expression of the catalytic subunit of
PP2A upregulates
v-Src- and v-HaRas induced TRE mediated gene expression, whereas PP2A downregulates v-Src- and v-HaRas induced SRE mediated gene expression