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ITIH4 — PDCD6
Text-mined interactions from Literome
Tuosto et al., Eur J Immunol 1995
:
We show that monomeric gp120 induces apoptosis only in T lymphocytes repeatedly stimulated with the antigen, that primary T lymphocytes are resistant to
programmed cell death mediated by monomeric
gp120 , but are sensitive to anti-CD4 antibodies, and that gp120 mediated apoptosis is dependent on the period of time between the binding of gp120 to CD4 and the encounter with antigen
Foster et al., Eur J Immunol 1995
(HIV Infections) :
gp120 induced
programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor
Siliciano et al., Curr Top Microbiol Immunol 1996
:
In addition, shed gp120 can bind to CD4 on noninfected cells and interfere with the function of these cells while at the same time rendering the cells susceptible to destruction by ADCC, by CD4+ CTLs or by
programmed cell death induced by cross linking of CD4 with
gp120 and anti-gp120 followed by cellular activation