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ABL1 — CYFIP1

Text-mined interactions from Literome

Leng et al., Proc Natl Acad Sci U S A 2005 : Abi-1 also couples WAVE2 to Abl after cell stimulation, an interaction that triggers Abl membrane translocation with WAVE2, Abi-1, and activated Rac, as well as Abl mediated tyrosine phosphorylation and WAVE2 activation ... By contrast, mutation of tyrosine residue Y150, identified here as the major site of Abl mediated WAVE2 tyrosine phosphorylation, as well as disruption of WAVE2-Abi-1 binding, impairs induction of WAVE2-driven actin polymerization and its membrane translocation in association with activated Rac
Stuart et al., J Biol Chem 2006 : We have demonstrated that Abl dependent phosphorylation of WAVE2 is necessary for its activation in vivo, which is highlighted by the findings that RNA interference of WAVE2 expression in Abl/Arg-/- cells has no additive effect on the amount of membrane ruffling ... Together, these data show that c-Abl activates WAVE2 via tyrosine phosphorylation to promote actin remodeling in vivo and that Abi-1 forms the crucial link between these two factors
Hirao et al., FEBS Lett 2006 : Previous studies showed that Abi-1 promotes c-Abl mediated phosphorylation of Mammalian Enabled ( Mena ) and WAVE2 ... Although Abi-2, like Abi-1, promoted the c-Abl mediated phosphorylation of Mena and WAVE2 , NESH ( Abi-3 ) had no such effect
Li et al., J Cell Sci 2007 : Bcr-Abl induced membrane translocation of Abi1/WAVE2 requires direct interaction between Abi1 and Bcr-Abl, but is independent of the phosphoinositide 3-kinase pathway
Harmon et al., PLoS Pathog 2010 (Astrocytoma...) : Rac and the tyrosine kinase Abl then activate the Wave2 complex and promote Arp2/3 dependent actin polymerization