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PLD1 — RHEB
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sun et al., Proc Natl Acad Sci U S A 2008
:
Here, we find that
PLD1 , but not PLD2, is
required for
Rheb activation of the mTOR pathway, as demonstrated by the effects of RNAi ... The overexpression of
Rheb activates PLD1 in cells in the absence of mitogenic stimulation, and the knockdown of Rheb
impairs serum stimulation of
PLD activation ... Finally,
Rheb binds and
activates PLD1 in vitro in a GTP dependent manner, strongly suggesting that PLD1 is a bona fide effector for Rheb
Avruch et al., Am J Physiol Endocrinol Metab 2009
:
In addition,
Rheb-GTP stimulates
phospholipase D1 to generate phosphatidic acid, a positive effector of mTORC1 activation, and binds to the mTOR inhibitor FKBP38, to displace it from mTOR ... The contribution of
Rheb 's
regulation of
PL-D1 and FKBP38 to mTORC1 activation, relative to Rheb 's direct binding to mTOR, remains to be fully defined