Gene interactions and pathways from curated databases and text-mining

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PTEN — SMAD3

Text-mined interactions from Literome

Hjelmeland et al., Cancer Res 2005 (Neoplasm Invasiveness) : RNA interference ( RNAi ) suppression of PTEN expression enhances SMAD3 transcriptional activity and TGF-beta mediated induction of SMAD3 target genes whereas reconstitution of PTEN in a null cancer cell line represses the expression of TGF-beta regulated target genes
Mathieu et al., Mol Cell Neurosci 2008 : Silencing Smad5 with siRNA or treatment with Noggin, a BMP antagonist, demonstrated that upregulation of PTEN in NSPCs required BMP/Smad signaling and that this pathway regulated cell cycle exit of NSPCs