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CD44 — RELA
Text-mined interactions from Literome
Gruber et al., Mol Immunol 2005
:
Consistently, after CD3/CD28 engagement, deficiency of PKCepsilon did not impair
NF-kappaB transactivation as well as CD25,
CD44 and CD69
induction
Gore et al., J Biol Chem 2008
:
We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to
NF-kappaB activation, proliferation, and survival in a CD74- and
CD44 dependent manner
Bourguignon et al., J Biol Chem 2009
(Breast Neoplasms) :
Further analyses indicate that activation of SIRT1 ( deacetylase ) by resveratrol ( a natural antioxidant ) induces SIRT1-p300 association and acetyltransferase inactivation, leading to deacetylation of
HA/CD44 induced beta-catenin and
NFkappaB-p65 , inhibition of beta-catenin-T-cell factor/lymphocyte enhancer factor and NFkappaB-specific transcriptional activation, and the impairment of MDR1 and Bcl-x ( L ) gene expression
Campo et al., Biochim Biophys Acta 2009
:
HA treatment produced different effects : low MW HA up-regulated
CD44 expression, increased PKCdelta and PKCepsilon levels, and
enhanced inflammation in untreated chondrocytes ; while in PMA treated cells it increased CD44, PKCdelta, PKCepsilon,
NF-kB , TNF-alpha, IL-1beta, MMP-13, and iNOS expression and enhanced the effects of PMA ; medium MW HA did not exert action ; high MW HA had no effect on untreated chondrocytes ; however, it reduced PKCdelta, PKCepsilon, NF-kB activation and inflammation in PMA stimulated cells
Damm et al., J Invest Dermatol 2010
(Lymphatic Metastasis...) :
HGF dependent
CD44v6 regulation in melanocytes is
NF-kappaB dependent because BAY 11-7082, an inhibitor of NF-kappaB activation, but not interference with the mitogen activated protein kinase or phosphatidylinositol 3-kinase cascade, antagonized HGF induced CD44v6 expression ...
NF-kappaB mediated transcriptional
regulation of
CD44v6 involves the transcription factors Egr-1 and CCAAT enhancer binding protein-beta ( C/EBP-beta )