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Text-mined interactions from Literome
Yu et al., J Am Soc Nephrol 2002
:
TSA inhibited induction of endogenous NO production and iNOS as well as
NF-kappa B element promoter activity in response to interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) in both cell types without altering NF-kappa B DNA binding activity
Rahman et al., Mol Cell Biochem 2002
(Inflammation) :
H2O2, and TNF-a, and
TSA all
increased NF-kappaB and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay
Yao et al., Pharmacol Res 2006
(Carcinoma...) :
Coincident with this observation,
TSA induced a concentration dependent reduction of constitutive and tumour necrosis factor (TNF)-alpha induced
NF-kappaB activation in Tca8113 cells ... Overall, our results indicate inhibition of
NF-kappaB activation
contributes , at least partially, to the antitumour activity of
TSA in human tongue carcinoma cells
Chang et al., Mol Immunol 2007
:
TSA1 could also
inhibit TNF induced cytotoxicity on L929 cells and TNF mediated
NF-kappaB activation on HEK-293T cells
Wang et al., J Biol Chem 2007
(Thrombosis) :
A chromatin immunoprecipitation assay and a promoter-luciferase reporter system confirm that
TSA inhibits TF-kappaB but not
NF-kappaB activation
Domingo-Domènech et al., Breast Cancer Res Treat 2008
(Breast Neoplasms) :
We observed that the HDACi suberoylanilide hydroxamic acid ( SAHA ) or
trichostatin A (TSA) induced cell death but also
enhanced NF-kappaB-activity
Chabane et al., Osteoarthritis Cartilage 2008
:
In the present study, we determined the
effect of
trichostatin A (TSA) and butyric acid ( BA ), two histone deacetylase (HDAC) inhibitors, on NO and PGE ( 2 ) synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and
nuclear factor (NF)-kappaB DNA binding activity, in interleukin-1beta (IL-1) stimulated human OA chondrocytes, and on IL-1 induced proteoglycan degradation in cartilage explants
Chavey et al., Mol Pharmacol 2008
(Breast Neoplasms) :
These observations are corroborated by an up-regulation of
NF-kappaB activity in MCF-7 cells in the
presence of
TSA
Dong et al., Phytother Res 2009
(Brain Ischemia...) :
In vitro, the translocation of
NF-kappaB was
inhibited by
TSA and the survival rate of astrocytes was markedly increased and the NO production was decreased
Wu et al., Gynecol Obstet Invest 2010
(Endometriosis) :
To determine whether nuclear factor-kappaB (NF-kappaB) is constitutively and tumor necrosis factor (TNF)-dependently activated in endometriotic cells, whether
trichostatin A (TSA) can
suppress NF-kappaB activation and suppress TRAF2/6 and TAK1, and whether TSA and caffeic acid phenyl ester can suppress constitutive and H ( 2 ) O ( 2 ) -stimulated proliferation of endometriotic cells ... Electrophoretic mobility shift analysis was used to determine
NF-kappaB activation and possible suppression by
TSA ... TNFalpha stimulation activated
NF-kappaB through induction of IkappaB phosphorylation, but the activation can be
suppressed by
TSA
Wang et al., FEBS Lett 2010
:
TSA-treatment inhibited nuclear translocation of
NF-kappaB following IgE mediated, but not LPS induced activation in MCs