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CDKN1A — MYLIP

Text-mined interactions from Literome

Reddy et al., Cancer Res 2008 (Breast Neoplasms...) : Here we show that microRNA-7 (miR-7) inhibits p21 activated kinase 1 (Pak1) expression, a widely up-regulated signaling kinase in multiple human cancers, by targeting the 3'-untranslated region ( UTR ) of Pak1 mRNA
Godlewski et al., Cancer Res 2008 (Glioma) : We found that miR-128 expression caused a decrease in histone methylation ( H3K27me ( 3 ) ) and Akt phosphorylation, and up-regulation of p21 ( CIP1 ) levels, consistent with Bmi-1 down-regulation
Braun et al., Cancer Res 2008 (Bone Neoplasms...) : On the other hand, miR-192 and its cousin miR-215 can each contribute to enhanced CDKN1A/p21 levels, colony suppression, cell cycle arrest, and cell detachment from a solid support ... Antagonizing endogenous miR-192 attenuated 5-fluorouracil induced accumulation of p21
Song et al., Oncogene 2009 (Bone Neoplasms...) : miR-140 induced p53 and p21 expression accompanied with G ( 1 ) and G ( 2 ) phase arrest only in cell lines containing wild type of p53
Gottwein et al., J Virol 2010 : Ectopically expressed KSHV miR-K1 specifically inhibited the expression of endogenous p21 in KSHV negative cells and strongly attenuated the cell cycle arrest that normally occurs upon p53 activation, yet miR-K1 did not prevent the induction of other p53-responsive genes
Liang et al., Hepatology 2010 (Liver Neoplasms) : Moreover, miR-125b increased p21Cip1/Waf1 expression and arrested cell cycle at G1 to S transition
Hu et al., PloS one 2011 (Colonic Neoplasms) : Regulation of p21 gene expression by miR-106b was assessed by 3 ' UTR luciferase reporter assays and transfection of specific miRNA mimics
Tsuchiya et al., Cancer Res 2011 (Colonic Neoplasms) : Induction of p21 was inhibited by miR-22 after exposure to the genotoxic agent Adriamycin ( doxorubicin ; Bedford Laboratories ), sensitizing cells to p53 dependent apoptosis
Wang et al., Haematologica 2012 (Hyperplasia...) : Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194, respectively
Pullamsetti et al., Am J Respir Crit Care Med 2012 (Airway Remodeling...) : Overexpression of miR-17 significantly reduced p21 expression and increased proliferation of smooth muscle cells
He et al., Cell Death Differ 2013 (Leukemia, Myeloid, Acute) : More intriguingly, miR-17 and miR-20a directly inhibit the p21 and STAT3 ( signal transducer and activator of transcription 3 ) expression, both of which can reverse miR-17/miR-20a mediated abrogation of HIF-1a induced differentiation
Wang et al., Eur J Cancer 2013 (Stomach Neoplasms) : Targeted inhibition of MDM2 in a miRNA mimic transfected gastric cancer cell line abolished miR-17-5p/20a function and inhibition of p21 expression ... MDM2 contributes to miR-17-5p/20a function and inhibition of p21 in gastric cancer, and may be a novel mechanism underlying the oncogenic roles of miR-17-5p/20a
Chang et al., PloS one 2013 (Lung Neoplasms) : Using quantitative PCR, we found that MIR promoted the expression levels of ATM ( ataxia telangiectasia mutated ), ATR ( ataxia-telangiectasia and Rad3 related and Rad3 related ), TP53 ( tumor protein p53 ), p21 ( CDKN1A, cyclin dependent kinase inhibitor 1A ) and GADD45 ( growth arrest and DNA-damage inducible ), but decreased the expression levels of cyclin B coding genes, CCNB1 and CCNB2, as well as CDK1 ( Cyclin dependent kinase 1 )
Shi et al., Biomed Pharmacother 2013 : Overexpression of miR-22 in vitro effectively suppressed CDKN1A expression and inhibited cell proliferation
Wang et al., FEBS Lett 2013 (Retinoblastoma) : Furthermore, overexpression of miR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 protein levels
Shen et al., Cell Biol Int 2013 (Endometrial Neoplasms) : Target prediction using TargetScan software identified p21 as a potential target for miR-17-5p , which was confirmed by luciferase reporter, qRT-PCR and Western blot assays