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HLA-DRB1 — IL10

Text-mined interactions from Literome

Rojas et al., Infect Immun 1999 : IL-10 down-regulated major histocompatibility complex ( MHC ) class I, MHC class II , CD40, B7-1, and B7-2 expression on M. tuberculosis infected monocytes to a greater extent than TGF-beta
te Velde et al., J Immunol 1992 : Recently, we showed that the cytokine IL-10 also affects MHC class II Ag expression
Williams et al., J Immunol 2004 : STAT3 DN also blocked IL-10 mediated inhibition of MHC class II and COX2 expression
Nylén et al., Scand J Immunol 2004 (Leishmaniasis) : Blocking of major histocompatibility complex ( MHC) class II with alpha-MHC class II antibodies markedly inhibited proliferation and interferon-gamma (IFN-gamma) production, whereas interleukin-10 production was not affected
Matsoukas et al., J Med Chem 2005 (Encephalomyelitis, Autoimmune, Experimental...) : The mutant cyclic peptides, the cyclo ( 91-99 ) [ Ala ( 96 ) ] MBP ( 87 ) ( - ) ( 99 ) and the cyclo ( 87-99 ) [ Arg ( 91 ) Ala ( 96 ) ] MBP ( 87 ) ( - ) ( 99 ), reported previously for suppressing, to a varying degree, autoimmune encephalomyelitis in a rat animal model, were found in this study to possess the following immunomodulatory properties : ( i ) they suppressed the proliferation of a CD4 T-cell line raised from a multiple sclerosis patient, ( ii ) they scored the best in vitro TH2/TH1 cytokine ratio in peripheral blood mononuclear cell cultures derived from 13 multiple sclerosis patients, inducing IL-10 selectively, and ( iii ) they bound to HLA-DR4 , first to be reported for cyclic MBP peptides
Lee et al., Int Immunopharmacol 2005 (Endometriosis) : IL-10 dependent down-regulation of MHC class II expression level on monocytes by peritoneal fluid from endometriosis patients
Tomoda et al., Immunology 1992 (Leukemia, Myeloid) : Among those cytokines, interleukin-1 beta (IL-1 beta) had a positive effect on IFN-gamma dependent induction of MHC class II genes
Choi et al., Eur J Immunol 2009 (Neoplasms) : In the present study, we found that IL-10 plays a major role in the tumor conditioned medium ( TCM ) -mediated decrease of MHC class II expression on BM-derived DC
Igyarto et al., J Immunol 2009 (Dermatitis, Contact...) : Both LC-derived IL-10 mediated suppression and full LC activation require LC expression of MHC class II
Enk et al., J Immunol 1993 : Initial studies failed to demonstrate effects of IL-10 on MHC class II Ag expression by LC or anti-CD3 mAb- or alloantigen induced LC-dependent T cell proliferation
Frei et al., J Immunol 1994 : The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed
LeClaire et al., Toxicology 1996 (Shock, Septic) : In a macrophage cell line, niacinamide ( ED50 -- 2mM ) and IL-10 ( ED50 -- 7U/ml ) inhibited interferon (IFN)-gamma induced MHC class II expression in a dose dependent manner
Koppelman et al., Immunity 1997 : Here we show that IL-10 does not affect MHC class II transcription, polypeptide synthesis, subunit assembly, or antigenic peptide loading
Allavena et al., Eur J Immunol 1998 : When added to already differentiated DC on day 6, IL-10 caused only a modest reduction of MHC class II and CD1a expression, and no acquisition of the macrophage markers CD14, CD16 and CD68
Xiao et al., J Neuroimmunol 1998 (Acute Disease...) : Most interestingly, nasally administered IL-10 also inhibited MHC class II expression in microglia, indicating that IL-10 administration by the nasal route prevents the activation of microglia