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CDK2 — MCM7
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zou et al., Mol Cell Biol 2000
:
Here we show that both Cdc45p and replication protein A (RPA) bind to
Mcm2p at the G ( 1 ) -S transition in an
S-CDK dependent manner
Ishimi et al., J Biol Chem 2003
:
Based on results that showed that the DNA helicase activity of the
MCM4-6-7 complex is negatively
regulated by
CDK2 phosphorylation, we suggest that the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex