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FGFR3 — PRL

Text-mined interactions from Literome

Pu et al., Neuroendocrinology 1999 (Calcium Signaling) : We used rat primary anterior pituitary ( AP ) cells to investigate how ACh affects pituitary prolactin (PRL) secretion in the presence or absence of known PRL regulators : thyrotropin releasing hormone (TRH), 17beta-estradiol ( E ( 2 ) ) and triiodothyronine ( T ( 3 ) ) ... ACh also inhibited both PRL responses elicited by drugs elevating intracellular cAMP ( 10 microM forskolin ) or Ca ( 2+ ) ( 1 microM Bay K-8644 ) in a PTX-sensitive manner ... ACh inhibition of basal PRL secretion was unaltered by intracellular Ca ( 2+ ) mobilization blockers, TMB-8 ( 100 microM ) and thapsigargin ( 1 microM ), but abrogated by the nitric oxide synthase inhibitor ( 300 microM L-NAME ) ... ACh inhibition of TRH induced PRL secretion was accentuated by TMB-8 and alleviated by thapsigargin or L-NAME ... Furthermore, nitric oxide mediated the basal rather than TRH induced PRL response to ACh, whereas the intracellular Ca ( 2+ ) mobilization concerned the TRH induced rather than the basal PRL response to ACh
Pu et al., J Cell Biochem 2002 : Aging also reduced the responsiveness of cells to ACh and DA in suppressing basal PRL secretion, and attenuated ACh inhibition of TRH induced PRL secretion ... Furthermore, ACh suppressed TRH induced PRL secretion mainly via the PMA-sensitive PKC in the old AP cells, but via additional mechanisms in young AP cells ... Taken together, these results suggest differential roles of PMA-sensitive PKC in regulating basal and ACh regulated PRL responses in old versus young AP cells
Hall et al., Gen Pharmacol 1985 : None of the antagonists except the cholinergic blocker, atropine, affected ACh induced release of prolactin ... Neither histamine nor ACh prevented inhibition of prolactin release by dopamine or stimulation of prolactin release by noradrenaline
Vijayan et al., Brain Res Bull 1980 : The participation of acetylcholine (Ach) in the control of gonadotropin and prolactin (Prl) release was evaluated in intact or pimozide treated conscious, ovariectomized ( OVX ) rats bearing indwelling 3rd ventricular and jugular venous cannulae by measuring plasma hormone levels by radioimmunoassay ( RIA )