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FGF2 — FLT1

Pathways - manually collected, often from reviews:

• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  

Text-mined interactions from Literome

Horiguchi et al., Endocrine 2004 : Regulation of VEGF-A, VEGFR-I , thrombospondin-1, -2, and -3 expression in a human pituitary cell line ( HP75 ) by TGFbeta1, bFGF , and EGF
Dutta et al., J Biol Chem 2008 (Neovascularization, Pathologic) : We demonstrate here that in endothelial cells, FGF2 and epidermal growth factor (EGF) signaling induce VEGFR1 mRNA expression in a combinatorial fashion ... EGF/FGF2 mediated VEGFR1 induction is mediated via functional interaction of transcription factors ETS1 and HIF-2alpha ... Knockdown of ETS1 and HIF-2alpha by RNA interference inhibits EGF/FGF2 induced VEGFR1 expression, and loss of expression is associated with impaired RNA-polymerase II recruitment and histone modifications at the VEGFR1 promoter region
Hughes-Fulford et al., Journal of orthopaedic surgery and research 2011 : We found that FGF-2 caused the most significant induction of expression of early growth response-1 (egr-1), fgf-2, cyclo-oxygenase-2 (cox-2), tgfß and matrix metalloproteinase-3 (mmp-3) associated with proliferation and expression of angiogenic genes like vascular endothelial growth factor A ( vegfA ) and its receptor vegfr1