Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
SMAD3
→
ACVR1C
(increases, ACVR1C Activity, SMAD3 Activity)
Kim et al., J Biol Chem 2004* Evidence: Investigation into the downstream targets and mechanisms involved in ALK7-induced apoptosis revealed that the TGF-beta signaling intermediates, Smad2 and -3, were activated, as well as the MAPKs JNK and p38. In addition, caspase-3 and -9 were also activated, and cytochrome c release from the mitochondria was observed
OpenBEL Selventa BEL large corpus:
SMAD3
→
ACVR1C
(increases, ACVR1C Activity, SMAD3 Activity)
Besser et al., J Biol Chem 2004* Evidence: Treatment of differentiating cells with Activin A leads to activation of Smad2/3 and expression of nodal, lefty-A and lefty-B, while inhibition of ALK4/5/7 by the kinase inhibitor SB-431542 blocks activation of Smad2/3