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CD14 — RELA
Pathways - manually collected, often from reviews:
-
KEGG Amoebiasis:
Complex of CD14-TLR2-TLR4
→
NFKB1/RELA
(protein-protein, activation)
Text-mined interactions from Literome
Jeon et al., Immunopharmacology 2000
:
In the present study, we investigated the
role of
CD14 and complement receptor type 3 ( CR3 ) in mediating NO production and
NF-kappaB/Rel activation induced by angelan and LPS
Corsini et al., Eur J Pharmacol 2001
:
The binding of lipopolysaccharide to its receptor
CD14 activates protein kinase C and
nuclear factor-kappaB (NF-kappaB)
Müller et al., Immunology 2001
(Translocation, Genetic) :
An approximately 70 % decrease of lipopeptide induced
NFkappaB translocation and an about 50 % reduction of nitric oxide ( NO ) release was observed in the
presence of
anti-CD14
Jeon et al., Int Immunopharmacol 2001
:
In conclusion, we demonstrate that angelan
induces NF-kappa B/Rel activation through the
CD14 and CR3 membrane receptor and p38 kinase that is critically involved in the signal transduction leading to NF-kappa B/Rel activation in murine macrophages
Maeda et al., J Biol Chem 2001
(Stomach Neoplasms) :
In conclusion, H. pylori induced
NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not
involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4
Narayanan et al., Cell Biol Int 2002
:
CD14 dependent activation of
NF-kappaB by filarial parasitic sheath proteins ... Herein we provide evidence that FPS activation of
NF-kappaB can be
augmented by the cell surface expression of
CD14 ... These observations suggest that the capacity of certain lung epithelial cells to interact with microfilarial antigens, activate
NF-kappaB in a
CD14 dependent manner and produce pro-inflammatory cytokines may be a contributory factor to immune responses manifested by tropical pulmonary eosinophilia
Muroi et al., Infect Immun 2002
:
These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS induced
activation of
NF-kappaB through human
CD14/TLR4/MD-2
Schilling et al., Infect Immun 2003
:
The LPS receptor complex utilized by the bladder epithelial cell lines included
CD14 and Toll-like receptors, and signaling
involved the activation of
NF-kappaB and p38 mitogen activated protein kinase
Hamann et al., Infect Immun 2005
(Acute-Phase Reaction) :
Here, we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to
CD14 and
inhibits LPS induced nuclear translocation of
NF-kappaB , although cellular uptake of R-type LPS was found to be increased by hd-LBP
Jeyaseelan et al., Infect Immun 2005
(Respiratory Distress Syndrome, Adult) :
Our results show that
CD14 and TLR4 are
necessary for low-dose ( 300-microg/ml ) LPS induced microvascular leakage,
NF-kappaB activation, neutrophil influx, cytokine and chemokine ( KC, macrophage inflammatory protein 2, tumor necrosis factor alpha, interleukin-6 ) expression, and subsequent lung damage
Ikeda et al., Immunopharmacol Immunotoxicol 2005
:
NF-kappaB activation via TLR2, TLR1/ TLR2, TLR2/TLR6, and
TLR4/MD-2/CD14 also was enhanced by stimulation with ZWS and ZWIS
Phan et al., Gene 2006
(Burns...) :
CD14 dependent modulation of
NF-kappaB alternative splicing in the lung after burn injury
Liu et al., Acta Pharmacol Sin 2006
(Drug-Induced Liver Injury) :
Upregulation of TNF-alpha and IL-6 mRNA might be related to increases in LBP and
CD14 mRNA expression and
activation of
NF-kappaB
Hayashi et al., Journal of thrombosis and haemostasis : JTH 2006
:
Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and
NFkappaB activation : involvement of membrane bound
CD14 and toll-like receptor-4 ... Antirat
CD14 and antirat TLR-4 antibodies
inhibited LPS induced
NFkappaB activation, and a NFkappaB inhibitor suppressed LPS induced decreased PS expression in both cells
Ji et al., Zhong Xi Yi Jie He Xue Bao 2006
:
QGHXR could down regulate the expressions of membrane receptors
CD14 and TLR(4) and
inhibit the expressions of
NF-kappaB and TNF-alpha
Gaudreault et al., J Virol 2007
:
NF-kappaB activation in HEK293-TLR2 cells ( HEK293 cells transfected with TLR2 ) by EBV was not
enhanced by the presence of
CD14
Nareika et al., J Endocrinol 2008
:
Further investigations using transcription factor activity assays and gel shift assays revealed that high glucose
augmented LPS stimulated
CD14 expression by enhancing transcription factor
nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1) activities
He et al., Clinical and vaccine immunology : CVI 2009
(Mycoplasma Infections) :
The activity of
NF-kappaB was synergically
augmented by cotransfected TLR1, TLR6, and
CD14
Chun et al., Int Immunopharmacol 2010
(Necrosis) :
CD14 played a significant role in the activation of
NF-kappaB in response to necrotic cells in the presence or absence of TLR2
Watson et al., Brain Behav Immun 2010
(Encephalitis) :
The evidence suggests that these changes are a likely consequence of increased hippocampal expression of
CD14 and TLR4, and
NFkappaB activation in SIGIRR ( -/- ) mice
Medvedev et al., J Immunol 1998
:
This study was undertaken to evaluate the
role of
CD14 and complement receptors type 3 ( CR3 ) and 4 ( CR4 ) in mediating TNF release and
NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS )