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NLRP3 — RELA
Text-mined interactions from Literome
Dowds et al., Biochem Biophys Res Commun 2003
(Familial Mediterranean Fever) :
Notably, pyrin, the product of the familial Mediterranean fever gene, inhibited
cryopyrin mediated apoptosis and
NF-kappaB activation by disrupting the cryopyrin-ASC interaction
O'Connor et al., J Immunol 2003
:
Transfection of full-length
CIAS1 or either of two shorter, naturally occurring isoforms dramatically
inhibited TNF-alpha induced activation of
NF-kappaB reporter activity
Hoffman et al., Lancet 2004
(Acute Disease...) :
Involvement of
cryopyrin in activation of caspase 1 and
NF-kappaB signalling suggests that it might have a role in many chronic inflammatory diseases
Yu et al., Cell Death Differ 2006
(Inflammation) :
Using a HEK293 cell based reconstitution system that stably expresses ASC and procaspase-1 we demonstrated that neither
cryopyrin nor pyrin or their corresponding disease associated mutants could significantly
activate NF-kappaB in this system
Saito et al., Arthritis Rheum 2005
(Chronic Disease...) :
In addition, the Y570C mutation ( with or without the S196N polymorphism ) increased the ability of
CIAS1 to
induce ASC dependent
NF-kappaB activation, unlike the wild-type gene or the gene bearing the S196N polymorphism alone
Fontalba et al., J Immunol 2007
:
Thus,
NLRP2 may
control NF-kappaB activation through a regulatory loop