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CSF1 — IL2

Text-mined interactions from Literome

Frei et al., J Neuroimmunol 1992 : Here we report that in addition to GM-CSF, murine astrocytes also produce macrophage (M)-CSF upon stimulation with tumor necrosis factor alpha, interleukin-1 and lipopolysaccharides
Schaafsma et al., Blood 1991 (Carcinoma, Renal Cell...) : The presence of IL-2 induced GM-CSF and M-CSF was also demonstrated by specific radioimmunoassays
Misago et al., Int J Hematol 1993 : Enhancing effects of IL-2 on M-CSF production by human peripheral blood monocytes ... Our findings here showed that interleukin-2 (IL-2) , at a concentration of more than 0.05 ng/ml, led to a 12-fold increase in the production of M-CSF in the human peripheral blood mononuclear cells after 72 h incubation compared to the control culture ... The enhancing effect of IL-2 on M-CSF secretion was also observed when IL-2 stimulated non-phagocytic cell conditioned medium was added to monocyte cultures
Hamilton et al., J Leukoc Biol 1993 : We demonstrate with elutriation purified human monocytes that, in contrast to lipopolysaccharide, recombinant human CSF-1 does not induce secretion of prostaglandin E2, interleukin-6 (IL-6), IL-1 beta, or tumor necrosis factor alpha, as measured by immunoassay ; however, increased urokinase-type plasminogen activator ( u-PA ) activity in cell lysates and mRNA was observed
Brach et al., J Immunol 1993 : Here we report that binding of human IL-2 to its binding site leads to transcriptional activation of the macrophage CSF (M-CSF) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody ... Transcriptional activation of the M-CSF gene by IL-2 is preceded by enhanced binding activity of the transcription factor NF-kappa B to its recognition sequence in the 5 ' regulatory enhancer region of the M-CSF gene ... Taken together, our findings indicate that IL-2 induces gene expression of M-CSF in human blood derived Mo and provide evidence for involvement of NF-kappa B in transcriptional regulation of this gene
Dupuis et al., Biochim Biophys Acta 1996 : While GM-CSF ( 10 ng/ml ) and interleukin-1 ( 10 U/ml ) stimulated M-CSF production from monocyte derived macrophages, PAF did not
Kutza et al., AIDS 1998 : IL-2 also increases M-CSF production and M-CSF receptor expression by human monocytes, but the subsequent effects on HIV-1 replication in MDM have yet to be determined