◀ Back to IL8

IL8 — TNFSF10

Text-mined interactions from Literome

Choi et al., Mol Cell Biol 2002 (Astrocytoma...) : We demonstrate that DR5 ligation by either TRAIL or TRA-8 induces two functional outcomes, apoptosis and expression of the chemokine interleukin-8 (IL-8) ; the nonspecific caspase inhibitor Boc-D-Fmk blocks both TRAIL mediated cell death and IL-8 production ; the caspase 3-specific inhibitor z-DEVD-Fmk suppresses TRAIL mediated apoptosis but not IL-8 induction ; caspase 1- and 8-specific inhibitors block both TRAIL mediated cell death and IL-8 production ; and DR5 ligation by TRAIL mediates AP-1 and NF-kappaB activation, which can be inhibited by caspase 1- and 8-specific inhibitors
Li et al., J Immunol 2003 : In surviving cells, TRAIL activates NF-kappaB, induces expression of E-selectin, ICAM-1, and IL-8 , and promotes adhesion of leukocytes
Wachter et al., J Biol Chem 2004 (Inflammation) : Surprisingly, cFLIP ( L ) specifically blocked TRAIL induced NF-kappaB activation and TRAIL dependent induction of the proinflammatory target gene interleukin-8
Varfolomeev et al., J Biol Chem 2005 : Apo2L/TRAIL induced secretion of interleukin-8 and monocyte chemoattractant protein-1, augmenting macrophage migration
Trauzold et al., Oncogene 2006 (Carcinoma, Pancreatic Ductal...) : Here, we show that TRAIL strongly induces the expression of the proinflammatory cytokines interleukin-8 and monocyte chemoattractant protein 1 and enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro by upregulation of the urokinase-type plasminogen activator expression
Levina et al., Exp Cell Res 2008 (Neoplasms) : TRAIL stimulated production of several cytokines, IL-8 , RANTES, MCP-1 and bFGF, and activation of caspases 1 and 8 was essential for this effect
Zhou et al., Hepatobiliary Pancreat Dis Int 2008 (Pancreatic Neoplasms) : The purpose of this study was to find out if TRAIL could induce the expression of uPA, IL-8 , MMP-7 and MMP-9.and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells ... TRAIL can stimulate the expression of uPA, IL-8 , MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt ... The members of caspases, MEK1/2, PKC, and NF-kappaB are involved in TRAIL induced expression of uPA, IL-8 , MMP-7 and MMP-9
Wilson et al., Mol Cancer Ther 2008 (Prostatic Neoplasms) : We conclude that endogenous and TRAIL induced IL-8 signaling can modulate the extrinsic apoptosis pathway in prostate cancer cells through direct transcriptional regulation of c-FLIP
Nguyen et al., Clin Immunol 2009 (Lupus Nephritis) : Functionally, TRAIL did not induce apoptosis but rather enhanced the proliferation of PTEC through activation of PI3 kinase/AKT and ERK1/2, increased IL-8 production and upregulated ICAM-1 expression
Zhou et al., Hepatobiliary Pancreat Dis Int 2013 (Adenocarcinoma...) : TRAIL induced expression of uPA and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells ... The purpose of this study was to investigate the roles of the pro-apoptotic TRAIL receptors, TRAIL-R1 and TRAIL-R2, as well as Bcl-xL and TRAF2 in TRAIL induced expression of the pro-inflammatory cytokine IL-8 and the invasion promoting protein urokinase ( uPA ) in pancreatic ductal adenocarcinoma ( PDAC ) cells ... Overexpression of TRAF2 or Bcl-xL strongly increased TRAIL mediated upregulation of uPA and IL-8 ... In PDAC cells, TRAIL strongly induced uPA and IL-8 via TRAIL-R1